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thapsigargin

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Origin: China

Cas No: 67526-95-8

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 67526-95-8 Formula: C34H50O12 Molecular Weight: 650.75400

    Description

    Thapsigargin is non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Structurally, thapsigargin is classified as a sesquiterpene lactone, and is extracted from a plant, Thapsia garganica. It is a tumor promoter in mammalian cells.
    Thapsigargin raises cytosolic (intracellular) calcium concentration by blocking the ability of the cell to pump calcium into the sarcoplasmic and endoplasmic reticula. Store-depletion can secondarily activate plasma membrane calcium channels, allowing an influx of calcium into the cytosol.
    Thapsigargin specifically inhibits the fusion of autophagosomes with lysosomes; the last step in the autophagic process. The inhibition of the autophagic process in turn induces stress on the endoplasmic reticulum which ultimately leads to cellular death.
    Thapsigargin is useful in experimentation examining the impacts of increasing cytosolic calcium concentrations.

    Basic Info

    Chemical Name thapsigargin
    Synonyms

    Thallium mononitrate;
    thallous nitrate TlNO3,orthorhombic;
    Thapsigargin;
    Pamoic acid disodium salt;
    THALLIUM NITRATE;
    THALLOUS NITRATE;
    sesquiterpene lactone tetraester;
    rcrawastenumberu217;
    thallous;
    sesquiterpene lactone;
    Thapsigargin,(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yloctanoate;

    CAS No. 67526-95-8
    Molecular Formula C34H50O12
    Molecular Weight 650.75400
    PSA 171.96000
    LogP 3.92790

    Properties

    Appearance & Physical State colourless film
    Storage Condition −20°C

    Safety Info

    Safety Statements S26; S36/37/39
    WGK Germany 3
    RIDADR UN 2811 6.1/PG 2
    Risk Statements R36/37/38; R42
    Hazard Codes Xn; T
    Hazard Declaration H315; H319; H334; H335
    Signal Word Danger
    Symbol GHS07, GHS08
    Caution Statement P261; P305 + P351 + P338; P342 + P311

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