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tangeretin

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Origin: China

Cas No: 481-53-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    Type:
    Herbal Extract
    Form:
    Powder
    Variety:
    tangerine peel extract
    Part:
    peel
    Extraction Type:
    Solvent Extraction
    Packaging:
    CAN, DRUM, fiber can
    Place of Origin:
    Shaanxi, China
    Grade:
    Pharma/Food Grade
    Brand Name:
    LISI
    Model Number:
    tangerine peel extract
    Product Name:
    Aurantium Extract / Tangerine Peel Extract Powder Hesperidin 98% HPLC
    Appearance:
    Yellow Brown or Light Yellow Off white powder
    Specification:
    98%
    Loss on drying:
    ≤ 2%
    Molecular formula:
    C20H20O7
    CAS NO:
    481-53-8
    Molecular weight:
    372.374
    Application:
    cosmetic industry, health product, pharmaceutical field
    Purity:
    98.0% Min
    Shelf Life:
    24 Months

    Packaging&Delivery

    Packaging Details
    Packed in paper-drums and two plastic-bags inside
    Net W. : 25KGs D38*H55
    Port
    tianjin
    Lead Time:
    Quantity(Kilograms)1 - 100>100
    Est. Time(days)1To be negotiated

  • Property

    CAS No.: 481-53-8 Formula: C20H20O7 Molecular Weight: 372.36900

    Description

    Tangeritin is an O-polymethoxylated flavone that is found in tangerine and other citrus peels. Tangeritin strengthens the cell wall and acts as a plant's defensive mechanism against disease-causing pathogens.
    It has also been used as a marker compound to detect contamination in citrus juices.
    Although few randomized, double-blind human studies have been done, animal research shows the potential of tangeritin as a cholesterol lowering agent. A study on rats demonstrated potential protective effects against Parkinson's disease.
    Tangeritin also shows enormous potential as an anti cancer agent. In in vitro studies, tangeritin appears to counteract some of the adaptations of cancer cells. Tangeritin induced apoptosis in leukemia cells while sparing normal cells. In a study on two human breast cancer cell lines and one colon cancer cell line, tangeritin blocked cell cycle progression at the G1 (growth) phase in all three cell lines, without inducing apoptosis in the tumor cell lines. Once tangeritin was removed from the tumor cells, their cell cycle progression returned to normal. Tangeritin also counteracts tumor suppression of gap junction intercellular signaling.

    Basic Info

    Chemical Name tangeretin
    Synonyms

    TANGERITIN;
    4',5,6,7,8-Pentamethoxyflavone;
    ponkanetin;
    TANGARETIN;
    Tangeritine;
    5,6,7,8,4'-pentamethoxyflavone;
    TANGERETIN,NATURAL;
    Tangeretin;

    CAS No. 481-53-8
    Molecular Formula C20H20O7
    Molecular Weight 372.36900
    PSA 76.36000
    LogP 3.50300

    Properties

    Appearance & Physical State yellow crystalline
    Density 1.244 g/cm3
    Boiling Point 565.3ºC at 760 mmHg
    Flash Point 248.4ºC
    Refractive Index 1.565
    Vapor Pressure 8.41E-13mmHg at 25°C

    Safety Info

    RTECS DJ3102725
    Safety Statements S45
    RIDADR UN 2811
    Risk Statements R25
    Hazard Codes T

    Synthesis Route

    4'-hydroxy-5,6,7,8-tetramethoxy flavone+iodomethane→tangeretin
    5,8-dihydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one+dimethyl sulfate→tangeretin
    1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)ethanone→tangeretin

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Capillary DB-1 310. 3162.9 isothermal
    Capillary HP-5MS - 3184. custom temperature program
    Capillary DB-5 - 3198. temperature ramp

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat >1 gm/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    iodomethane
    1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)ethanone
    dimethyl sulfate
    4'-hydroxy-5,6,7,8-tetramethoxy flavone

    Downstream Product

    2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one
    5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
    2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one
    gardenin B

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