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Tandospirone

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Origin: China

Cas No: 87760-53-0

Specification: 99%min

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Products Specification
Product Description

Property
CAS No.: 87760-53-0 Formula: C21H29N5O2 Molecular Weight: 383.48700

Description
Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.

Basic Info

Chemical Name Tandospirone

Synonyms
[14C]-Tandospirone;

CAS No. 87760-53-0

Molecular Formula C21H29N5O2

Molecular Weight 383.48700

PSA 69.64000

LogP 1.35070

Properties

Density 1.239g/cm3

Boiling Point 613.9ºC at 760 mmHg

Refractive Index 1.589

Storage Condition Store at +4ºC

Synthesis Route
(1R*,2S*,3R*,4S*)-N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]-2-butynyl]-2,3-bicyclo[2.2.1]heptanedicarboximide→Tandospirone
2-(1-Piperazinyl)pyrimidine+(1R,2S,3R,4S)-N-(4-bromobutyl)-2,3-bicyclo<2.2.1>heptanedicarboximide→Tandospirone
exo-3,6-Methylene-1,2,3,6-tetrahydrophthalic anhydride→Tandospirone

Precursor
(1R,2S,3R,4S)-N-(4-bromobutyl)-2,3-bicyclo<2.2.1>heptanedicarboximide
(1R*,2S*,3R*,4S*)-N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]-2-butynyl]-2,3-bicyclo[2.2.1]heptanedicarboximide
(3aR,4S,7R,7aS)-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
2-(1-Piperazinyl)pyrimidine

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