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Tabimorelin

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Origin: China

Cas No: 193079-69-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 193079-69-5 Formula: C68H84N8O10 Molecular Weight: 1173.44000

Description

NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.

Basic Info

Chemical Name	Tabimorelin
Synonyms	(E)-5-amino-N,5-dimethyl-N-[(2R)-1-[methyl-[(2R)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide;
CAS No.	193079-69-5
Molecular Formula	C68H84N8O10
Molecular Weight	1173.44000
PSA	266.08000
LogP	9.31140

Properties

Density	1.146g/cm3
Boiling Point	794.4ºC at 760mmHg
Flash Point	434.2ºC
Refractive Index	1.6
Vapor Pressure	0mmHg at 25°C

Synthesis Route

((3E)-1,1-Dimethyl-4-(N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)but-3-enyl)carbamic acid tert-butyl ester→Tabimorelin
Boc-N-Me-Phe-OH→Tabimorelin
N-Boc-3-amino-3-methylbutanoic Acid→Tabimorelin

Precursor

N-Boc-3-amino-3-methylbutanoic Acid
(1,1-dimethyl-3-oxo-propyl)-carbamic acid tert-butyl ester
((3E)-1,1-Dimethyl-4-(N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoyl)-2-(2-naphthyl)ethyl)carbamoyl)but-3-enyl)carbamic acid tert-butyl ester
BOC-N-METHYL-D-2-NAPHTHYLALANINE

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