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swainsonine

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Origin: China

Cas No: 72741-87-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 72741-87-8 Formula: C8H15NO3 Molecular Weight: 173.21000

    Description

    Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. As a toxin in locoweed (likely its primary toxin) it also is a significant cause of economic losses in livestock industries, particularly in North America.

    Basic Info

    Chemical Name swainsonine
    Synonyms

    D-Swainsonine;
    SWAINSONINE;
    8A,B-INDOLIZIDINE-1,2A,8B-TRIOL;
    (1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol;
    Tridolgosir;
    SwainMoia;
    swainsonine synthetic;
    (1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol;

    CAS No. 72741-87-8
    Molecular Formula C8H15NO3
    Molecular Weight 173.21000
    PSA 63.93000
    LogP -1.51500

    Properties

    Appearance & Physical State lyophilized powder
    Density 1.38 g/cm3
    Boiling Point 353.3ºC at 760 mmHg
    Melting Point 148-149ºC
    Flash Point 209.7ºC
    Refractive Index 1.608
    Storage Condition 2-8ºC

    Safety Info

    Safety Statements S36
    Risk Statements R20/21/22
    Hazard Codes Xn
    Hazard Declaration H302; H312; H332
    Signal Word Warning
    Symbol GHS07
    Caution Statement P280

    Synthesis Route

    (-)-8-benzyloxy-swainsonine→swainsonine
    (3aR,9R,9aR,9bS)-2,2-dimethyl-3a,4,6,7,8,9,9a,9b-octahydro-[1,3]dioxolo[4,5-a]indolizin-9-ol→swainsonine
    3-((2R,3S,4S,5S,6S)-3-azido-6-(benzyloxy)-tetrahydro-4,5-dihydroxy-2H-pyran-2-yl)propyl methanesulfonate→swainsonine

    Precursor

    Acetic acid (1S,2R,8R,8aR)-1,2-diacetoxyoctahydroindolizin-8-yl ester
    (-)-8-benzyloxy-swainsonine
    (1S,2R,8R,8aR)-octahydro-8-hydroxy-1,2-bis(phenylmethoxy)indolizine
    (3aR,9R,9aR,9bS)-2,2-dimethyl-3a,4,6,7,8,9,9a,9b-octahydro-[1,3]dioxolo[4,5-a]indolizin-9-ol

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