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SB-202190

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Origin: China

Cas No: 152121-30-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 152121-30-7 Formula: C20H14FN3O Molecular Weight: 331.34300

Description

SB 202190 is a DFG inhibitor used in the treatment of colorectal cancer. It is a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat.

Basic Info

Chemical Name	SB-202190
Synonyms	4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; FHPI; 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one;
CAS No.	152121-30-7
Molecular Formula	C20H14FN3O
Molecular Weight	331.34300
PSA	61.80000
LogP	4.65040

Properties

Appearance & Physical State	pale yellow
Density	1.311g/cm3
Boiling Point	565.705ºC at 760 mmHg
Flash Point	295.928ºC
Refractive Index	1.653
Vapor Pressure	0mmHg at 25°C

Safety Info

Safety Statements	S26-S36/37
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

6-(5-(6-(1-oxidaneyl)-13,23,34,43,53,64-hexaoxin-3-yl)-2-(13,23,33,44,53,63-hexaoxin-4-yl)-1-(1-oxidaneyl)-1H-13,24,34,43,54-pentaoxol-3-yl)-13,23,34,43,53,64-hexaoxin-3-ol→SB-202190
4-Fluoro-N-Methoxy-N-Methylbenzamide→SB-202190
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridine→SB-202190

Precursor

1-(4-fluorophenyl)-2-pyridin-4-ylethanone
4-methylpyridine
4-(((tert-Butyldimethylsilyl)oxy)methyl)pyridine
4-Fluoro-N-Methoxy-N-Methylbenzamide

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