Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Intermediates> (S)-4-Chloro-3-hydroxybutyronitrile

(S)-4-Chloro-3-hydroxybutyronitrile

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 127913-44-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

Products Specification
Product Description

Quick Details
CAS No.:
127913-44-4
Other Names:
(S)-4-Chloro-3-hydroxybutyronitrile
MF:
C4H6ClNO
EINECS No.:
/
Place of Origin:
Shandong, China
Type:
Pharmaceutical Intermediates
Purity:
99.0%
Brand Name:
Ocean
Model Number:
TOP
Application:
Used
Appearance:
Colorless Liquid
Product name:
(S)-4-Chloro-3-hydroxybutyronitrile
Molecular Weight:
119.55
Assay:
99.0%
Color:
Colorless
Density:
1.250 g/mL at 20 °C(lit.)
Boiling point:
110 °C/1 mmHg(lit.)
Packing:
25kg/drum
Storage:
Cool Dry Place
Packaging&Delivery
Packaging Details
25kg/drum,1kg/bag or according to customer request
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 15 To be negotiated

Property

CAS No.: 127913-44-4 Formula: C4H6ClNO Molecular Weight: 119.55000

Description

(3S)-4-Chloro-3-hydroxybutyronitrile is used in various organic precursor syntheses. It is used in the synthesis of hydroxypyrrolidinones to by used as carbapenem precursors. Also used in the preparation of atorvastatin precursors. Impurity in the synthesis of Rosuvastatin, a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.

Basic Info

Chemical Name	(S)-4-Chloro-3-hydroxybutyronitrile
Synonyms	(3S)-4-chloro-3-hydroxybutanenitrile;
CAS No.	127913-44-4
Molecular Formula	C4H6ClNO
Molecular Weight	119.55000
PSA	44.02000
LogP	0.49978

Properties

Appearance & Physical State	colorless to light yellow liquid
Boiling Point	110ºC (1 torr)
Flash Point	110ºC
Refractive Index	n20/D 1.474(lit.)
Vapor Pressure	0.000304mmHg at 25°C

Safety Info

Safety Statements	S28-S36/37-S45
HS Code	2942000000
Risk Statements	R23/24/25
Hazard Codes	Xi

Synthesis Route

1,3-dichloropropan-2-ol+potassium cyanide→(R)-4-Chloro-3-Hydroxybutyronitrile+(S)-4-Chloro-3-hydroxybutyronitrile
potassium cyanide+epichlorohydrin→(R)-4-Chloro-3-Hydroxybutyronitrile+(S)-4-Chloro-3-hydroxybutyronitrile
(S)-epichlorohydrin+Sodium cyanide→(S)-4-Chloro-3-hydroxybutyronitrile

Precursor

Trimethylsilyl Cyanide
(S)-epichlorohydrin
sodium cyanide
(2RS,4S)-2-oxo-4-chloromethyl-1,3,2-dioxathiolane

Downstream Product

Ethyl 4-chloro-3-hydroxybutanoate
(S)-3-Hydroxypyrrolidine hydrochloride

Hot tags: (s)-4-chloro-3-hydroxybutyronitrile, China, manufacturers, suppliers, factory, wholesale, low price, high quality