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Picture of (R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester

(R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester

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Origin: China

Cas No: 72657-23-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 72657-23-9 Formula: C5H10O3 Molecular Weight: 118.13100

    Description

    Roche ester (methyl 3-hydroxy-2-methylpropionate) is a chemical compound with formula C5H10O3. It can exist as two enantiomers. Both are commercially available and have been widely used as starting blocks for the synthesis of many targets including dictyostatin, discodermolide and spongidepsin.

    Basic Info

    Chemical Name (R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester
    Synonyms

    (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER;

    CAS No. 72657-23-9
    Molecular Formula C5H10O3
    Molecular Weight 118.13100
    PSA 46.53000
    LogP -0.21220

    Properties

    Appearance & Physical State Clear Colorless Oil
    Density 1.066
    Boiling Point 76-77ºC (12 MMHG)
    Flash Point 80ºC
    Refractive Index 1.425
    Storage Condition 2-8ºC

    Safety Info

    Safety Statements S16
    HS Code 2918199090
    WGK Germany 3
    Risk Statements R10

    Synthesis Route

    Methyl 2-(hydroxymethyl)acrylateMethyl (S)-(+)-3-Hydroxy-2-Methylpropionate+(R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester
    (R)-(-)-methyl 3-hydroxy-2-methylpropionateMethyl (S)-(+)-3-Hydroxy-2-Methylpropionate+(R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester
    diazomethane+(2R)-3-hydroxy-2-methylpropanoic acidMethyl (S)-(+)-3-Hydroxy-2-Methylpropionate+(R)-(-)-3-Hydroxy-2-Methylpropionic Acid Methyl Ester

    Precursor

    diazomethane
    (2R)-3-hydroxy-2-methylpropanoic acid
    Methyl 2-(hydroxymethyl)acrylate
    (R)-(-)-methyl 3-hydroxy-2-methylpropionate

    Downstream Product

    1-methoxy-4-[(4-methoxyphenyl)methoxymethyl]benzene
    methyl (2R)-3-[tert-butyl(dimethyl)silyl]oxy-2-methylpropanoate
    (2S)-3-{[tert-Butyl(dimethyl)silyl]oxy}-2-methylpropan-1-ol
    7-(5-hydroperoxy-13,24,33,43,54,63-hexaoxin-2-yl)-4-hydroxy-34,43-heptaoxidan-3-one

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