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Prostaglandin F2α tris salt

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Origin: China

Cas No: 38562-01-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    38562-01-5
    Other Names:
    PGF2a
    MF:
    C24H45NO8, C24H45NO8
    EINECS No.:
    254-002-3
    Place of Origin:
    Shandong, China
    Type:
    Endocrine System Agents
    Grade Standard:
    Medicine Grade
    Brand Name:
    HAIHANG
    Model Number:
    HHJH 38562-01-5
    Purity:
    96%~102%
    Product Name:
    Prostaglandin F2a tris salt
    CAS:
    38562-01-5
    Appearance:
    White Powder
    MW:
    475.62
    Melting point:
    -20°
    form:
    powder
    Color:
    white
    Water:
    <1%
    Assay:
    96%~102%

    Packaging&Delivery

    Packaging Details
    Prostaglandin F2a tris salt ( Dinoprost trometamol ) CAS No 38562-01-5
    Bags,1g,10g,100g,1kg, Or according to your requirement.
    Port
    Shanghai ,Qingdao , Dalian , Tianjing
    Lead Time:
    Quantity(Grams)1 - 100101 - 10001001 - 5000>5000
    Est. Time(days)357To be negotiated

  • Property

    CAS No.: 38562-01-5 Formula: C24H45NO8 Molecular Weight: 475.61600

    Description

    Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed dinoprost (INN), is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
    In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the follicular phase. It acts on the corpus luteum to cause luteolysis, forming a corpus albicans and stopping the production of progesterone. Action of PGF2α is dependent on the number of receptors on the corpus luteum membrane.
    The PGF2α isoform 8-iso-PGF2α was found in significantly increased amounts in patients with endometriosis, thus being a potential causative link in endometriosis-associated oxidative stress.

    Basic Info

    Chemical Name Prostaglandin F2α tris salt
    Synonyms

    Dinoprost trometamol;
    Prostaglandin F2a tris salt;

    CAS No. 38562-01-5
    Molecular Formula C24H45NO8
    Molecular Weight 475.61600
    PSA 184.70000
    LogP 1.40400

    Properties

    Boiling Point 531ºC at 760 mmHg
    Melting Point 25-35ºC
    Flash Point 289ºC
    Storage Condition -20ºC

    Safety Info

    Safety Statements 53-45
    HS Code 2937500000
    Risk Statements R60; R22
    Hazard Codes T
    Symbol GHS07, GHS08
    Signal Word Danger
    Caution Statement P201; P308 + P313
    Hazard Declaration H302; H360

    Synthesis Route

    (S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-(2-methylphenyl)ureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-phenylpropionic acid→Prostaglandin F2α tris salt
    (S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-phenylureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(4-methoxyphenyl)propionic acid→Prostaglandin F2α tris salt
    (S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-phenylureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(2,4-dimethoxyphenyl)propionic acid→Prostaglandin F2α tris salt

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 665 mg/kg 1.Behavioral-somnolence (general depressed activity)
    2.Lungs, Thorax, or Respiration-respiratory depression
    3.Skin and Appendages-hair
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 101 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous LD50 - Lethal dose, 50 percent kill Rodent - rat 66 mg/kg 1.Behavioral-altered sleep time (including change in righting reflex)
    2.Behavioral-somnolence (general depressed activity)
    3.Lungs, Thorax, or Respiration-respiratory stimulation

    Precursor

    (S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-phenylureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(2,4-dimethoxyphenyl)propionic acid
    (S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-(2-methylphenyl)ureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-phenylpropionic acid
    (S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-phenylureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(4-methoxyphenyl)propionic acid
    (S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-(2-methylphenyl)ureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(4-methoxyphenyl)propionic acid

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