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oxo-[[1-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxymethyl]pyridin-4-ylidene]methyl]azanium

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Origin: China

Cas No: 7683-36-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 7683-36-5 Formula: C14H16N4O3++ Molecular Weight: 288.30200

Description

Obidoxime is a member of the oxime family used to treat nerve gas poisoning. Oximes are drugs known for their ability to reverse the binding of organophosphorus compounds to the enzyme acetylcholinesterase (AChE).
AChE is an enzyme that removes acetylcholine from the synapse after it creates the required stimulation on the next nerve cell. If it gets inhibited, acetylcholine is not removed after the stimulation and multiple stimulations are made, resulting in muscle contractions and paralysis.
Organophosphates (such as nerve gases) are well-known inhibitors of AChE. They bind to a specific place on the enzyme and prevent it from functioning normally by changing the OH group on the serine residue and by protonating (quaternary nitrogen, R4N+) the nearby nitrogen atom located in the histidine residue.

Basic Info

Chemical Name	oxo-[[1-[[4-(oxoazaniumylmethylidene)pyridin-1-yl]methoxymethyl]pyridin-4-ylidene]methyl]azanium
Synonyms	Obidoxime; Obidoxime tablets; Obidoxim; Obidoxim kation; Obidoximum;
CAS No.	7683-36-5
Molecular Formula	C14H16N4O3++
Molecular Weight	288.30200
PSA	81.17000
LogP	-2.34640

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human	39 mg/kg	1.Peripheral Nerve and Sensation-paresthesis 2.Behavioral-muscle weakness 3.Gastrointestinal-nausea or vomiting
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	203 mg/kg	1.Peripheral Nerve and Sensation-flaccid paralysis without anesthesia (usually neuromuscular blockage) 2.Biochemical-Enzyme inhibition, induction, or change in blood or tissue levels-true cholinesterase

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