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N,N'-Disuccinimidyl carbonate

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Origin: China

Cas No: 74124-79-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 74124-79-1 Formula: C9H8N2O7 Molecular Weight: 256.16900

    Description

    N,N′-Disuccinimidyl Carbonateis a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins. The coupling reagent property of N,N’-Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.

    Basic Info

    Chemical Name N,N'-Disuccinimidyl carbonate
    Synonyms

    bis(2,5-dioxopyrrolidin-1-yl) carbonate;
    DSC;

    CAS No. 74124-79-1
    Molecular Formula C9H8N2O7
    Molecular Weight 256.16900
    PSA 110.29000
    LogP -0.85660

    Properties

    Appearance & Physical State white crystals
    Density 1.69g/cm3
    Boiling Point 383.7ºC at 760 mmHg
    Melting Point 190ºC
    Flash Point 185.9ºC
    Refractive Index 1.596
    Stability Stable at room temperature in closed containers under normal storage and handling conditions. Moisture sensitive.
    Storage Condition 2-8ºC

    Safety Info

    Safety Statements S26-S37/39
    HS Code 29299000
    WGK Germany 3
    Risk Statements R36/37/38
    Hazard Codes Xi
    Signal Word Warning
    Caution Statement P301 + P312 + P330; P305 + P351 + P338
    Hazard Declaration H302; H315; H319; H335
    Symbol GHS07

    Synthesis Route

    N-Hydroxysuccinimide+bis(trichloromethyl) carbonate→N,N'-Disuccinimidyl carbonate
    N-Hydroxysuccinimide+Diphosgene→N,N'-Disuccinimidyl carbonate

    Precursor

    N-Hydroxysuccinimide
    Diphosgene
    bis(trichloromethyl) carbonate

    Downstream Product

    (2,5-dioxopyrrolidin-1-yl) (2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoate
    N-Succinimidyl 6-maleimidohexanoate
    (2,5-dioxopyrrolidin-1-yl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
    (2,5-dioxopyrrolidin-1-yl) 2-methylsulfonylethyl carbonate

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