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midostaurin

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Origin: China

Cas No: 120685-11-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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CAS No.: 120685-11-2 Formula: C35H30N4O4 Molecular Weight: 570.63700

Description

Midostaurin (PKC412) is a multi-target protein kinase inhibitor being investigated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). It is a semi-synthetic derivative of staurosporine, an alkaloid from the bacterium Streptomyces staurosporeus, and is active in patients with mutations of CD135 (FMS-like tyrosine kinase 3 receptor, FLT3).
After successful Phase II clinical trials, a Phase III trial for AML has started in 2008. It is testing midostaurin in combination with daunorubicin and cytarabine. In another trial, the substance has proven ineffective in metastatic melanoma.

Basic Info

Chemical Name	midostaurin
Synonyms	4'-N-benzoylstaurosporine; PKC 412,[9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide; Cgp 41 251; 4'-N-benzoyl staurosprine; Midostaurin; Benzoylstaurosporine;
CAS No.	120685-11-2
Molecular Formula	C35H30N4O4
Molecular Weight	570.63700
PSA	77.73000
LogP	6.23560