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midostaurin

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Origin: China

Cas No: 120685-11-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 120685-11-2 Formula: C35H30N4O4 Molecular Weight: 570.63700

    Description

    Midostaurin (PKC412) is a multi-target protein kinase inhibitor being investigated for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). It is a semi-synthetic derivative of staurosporine, an alkaloid from the bacterium Streptomyces staurosporeus, and is active in patients with mutations of CD135 (FMS-like tyrosine kinase 3 receptor, FLT3).
    After successful Phase II clinical trials, a Phase III trial for AML has started in 2008. It is testing midostaurin in combination with daunorubicin and cytarabine. In another trial, the substance has proven ineffective in metastatic melanoma.

    Basic Info

    Chemical Name midostaurin
    Synonyms

    4'-N-benzoylstaurosporine;
    PKC 412,[9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide;
    Cgp 41 251;
    4'-N-benzoyl staurosprine;
    Midostaurin;
    Benzoylstaurosporine;

    CAS No. 120685-11-2
    Molecular Formula C35H30N4O4
    Molecular Weight 570.63700
    PSA 77.73000
    LogP 6.23560

    Properties

    Density 1.46g/cm3
    Refractive Index 1.76
    Storage Condition Store at 2-8ºC

    Safety Info

    Hazard Codes T

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