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methyl 5-[tert-butyl(dimethyl)silyl]oxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate

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Origin: China

Cas No: 96014-55-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 96014-55-0 Formula: C17H35NO5Si Molecular Weight: 361.54900

Basic Info

Chemical Name	methyl 5-[tert-butyl(dimethyl)silyl]oxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate
Synonyms	(S)-4-[[(TERT-BUTOXY)CARBONYL]AMINO]-5-[[(TERT-BUTYL)DIMETHYLSILYL]OXY]PENTANOIC ACID METHYL ESTER; (R)-METHYL 4-(TERT-BUTOXYCARBONYLAMINO)-5-(TERT-BUTYLDIMETHYLSILYLOXY)PENTANOATE; Methyl (4S)-4-(N-(tert-Butoxycarbonyl)amino)-5-((tert-butyldimethylsilyl)oxy)pentanoate;
CAS No.	96014-55-0
Molecular Formula	C17H35NO5Si
Molecular Weight	361.54900
PSA	73.86000
LogP	4.24560

Properties

Density	0.983
Boiling Point	408.1ºC at 760 mmHg
Flash Point	200.6ºC
Refractive Index	1.447

Synthesis Route

1-Pyrrolidinecarboxylic acid, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-oxo-, 1,1-dimethylethyl ester, (2S)-→methyl 5-[tert-butyl(dimethyl)silyl]oxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate
(S)-Methyl 4-[(tert-butoxycarbonyl)amino]-5-hydroxypentanoate+tert-butyldimethylsilyl chloride→methyl 5-[tert-butyl(dimethyl)silyl]oxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate
L-Glutamic acid 5-methyl ester→methyl 5-[tert-butyl(dimethyl)silyl]oxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate

Precursor

tert-butyldimethylsilyl chloride
L-Glutamic acid 5-methyl ester
tert-butoxycarbonyl anhydride
1-Pyrrolidinecarboxylic acid, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-5-oxo-, 1,1-dimethylethyl ester, (2S)-

Downstream Product

(S)-5-(((tert-Butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one
(S)-Methyl 4-[(tert-butoxycarbonyl)amino]-5-hydroxypentanoate

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