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Methyl 4-bromocrotonate

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Origin: China

Cas No: 1117-71-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 1117-71-1 Formula: C5H7BrO2 Molecular Weight: 179.01200

Description

Methyl 4-Bromocrotonate is a useful synthetic intermediate. It was used in the synthesis of irreversible inhibitors of EGFR and HER-2 tyrosine kinases with enhanced antitumor activities.

Basic Info

Chemical Name	Methyl 4-bromocrotonate
Synonyms	methyl4-bromo-2-butenoate; Methyl trans-4-Bromo-2-butenoate; TRANS-METHYL-4-BROMOCROTONATE; Methyl bromocrotonate; methyl 4-bromo-crotonate; 2-Butenoic acid, 4-bromo-, methyl ester; 4-bromocrotonic acid methyl ester; Methyl 4-Bromocrotonate; trans-4-Bromo-2-butenoic Acid Methyl Ester; Methyl 4-bromobut-2-enoate; Methyl Trans-4-Bromocrotonate;
CAS No.	1117-71-1
Molecular Formula	C5H7BrO2
Molecular Weight	179.01200
PSA	26.30000
LogP	1.11050

Properties

Appearance & Physical State	clear slightly yellow liquid
Density	1.522
Boiling Point	83-85ºC (13 mmHg)
Flash Point	91ºC
Refractive Index	1.499-1.502
Stability	Stable under normal temperatures and pressures.
Storage Condition	2-8ºC
Vapor Pressure	0.358mmHg at 25°C

Safety Info

RTECS	GQ3120000
Hazard Class	8
Safety Statements	S26-S36/37/39-S45
HS Code	2916190090
Packing Group	III
WGK Germany	3
RIDADR	UN1760
Risk Statements	R20/21/22; R34
Hazard Codes	C

Synthesis Route

trans-Methyl crotonate→Methyl 4-bromocrotonate
2-butenoic acid→Methyl 4-bromocrotonate
trans-Methyl crotonate→Methyl 4-bromocrotonate+γ-bromocrotonic acid methyl ester

Precursor

trans-Methyl crotonate
2-butenoic acid
tetrachloromethane
methyl 4-phenylselanylbut-2-enoate

Downstream Product

trans-Methyl crotonate
methyl 2-(2,3-dihydro-1,4-benzoxathiin-2-yl)acetate
methyl 2-(1-hydroxyethyl)but-2-enoate
methyl but-3-enoate

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