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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Intermediates> Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
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Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

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Origin: China

Cas No: 147118-35-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    147118-35-2
    Other Names:
    147118-35-2
    MF:
    C31H39O4PSi
    EINECS No.:
    147118-35-2
    Place of Origin:
    China
    Type:
    Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates
    Purity:
    ≥98%
    Brand Name:
    FinerChem
    Model Number:
    147118-35-2
    Application:
    Rosuvastatin intermediate
    Appearance:
    Light yellow to white crystalline powder
    CAS:
    147118-35-2
    Assay:
    98.0 %min
    Molecular Weight:
    534.70

    Packaging&Delivery

    Packaging Details
    Aluminum foil bag for within 10kg
    Fiber drum for 10kg and more
    Port
    SHANGHAI, BEIJING, QINGDAO, SHENZHEN, TIANJIN
    Lead Time:
    Quantity(Kilograms)1 - 500>500
    Est. Time(days)4To be negotiated

    Products Description

    Product Name
    Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
    CAS No.
    147118-35-2
    Appearance
    Light yellow to white crystalline powder
    Assay
    ≥98%
    Capacity
    200mt/year
    Min.packing
    1gram
    Application
    Rosuvastatin intermediate
    Standard
    Export 
    Brand
    Finerchem 


    More information

    Molecular Formula: C31H39O4PSi 
    Molecular Weight: 534.70 
    CAS Registry Number: 147118-35-2

  • Property

    CAS No.: 147118-35-2 Formula: C31H39O4PSi Molecular Weight: 534.69800

    Description

    Methyl (3R)-3-(tert-Butyldimethylsilanyloxy)-5-oxo-6-(triphenylphosphanylidene)hexanoate was used to preapre pyrimidinyl- and pyrrolylheptenoates with HMG-CoA reductase inhibitory activities.

    Basic Info

    Chemical Name Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
    Synonyms

    (R)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxo]-5-oxo-6-(triphenylphosphoranylidene)-methyl hexanoate;
    methyl-(3R)-3-[(terbutyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidene hexanoate;
    methyl (3R)-3[[tert-butyl-(dimethyl)silyl]oxy]-5-oxo-6-(triphenylphosphoranylidine)hexanoate;
    3-(tert-butyldimethylsilanyloxy)-5-oxo-6-(triphenylphosphanylidene)hexanoic acid methyl ester;
    (3R)-3-(tert-butyldiMethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate Methyl ester;
    METHYL (3R)-3-(TERT-BUTYLDIMETHYL SILYLOXY)-5-OXO-6-TRIPHENYL PHOSPHORANYLIDENE HEXANOATE (J6);
    rosuvastatin interMediates J-6;
    B-8;
    methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-(triphenylphosphoranylidene)hexanoate;

    CAS No. 147118-35-2
    Molecular Formula C31H39O4PSi
    Molecular Weight 534.69800
    PSA 62.41000
    LogP 5.69540

    Properties

    Appearance & Physical State Yellowish to White Crystalline Powder
    Density 1.1 g/cm3
    Boiling Point 603.9ºC at 760 mmHg
    Melting Point 77.5-78.5ºC
    Flash Point 319ºC

    Synthesis Route

    (R)-methyl 3-((tert-butyldimethylsilyl)oxy)-6-chloro-5-oxohexanoate+Triphenylphosphine→Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
    +Triphenylphosphine→Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate
    methyl triphenylphosphonium bromide+(R)-3-((tert-Butyldimethylsilyl)oxy)-5-methoxy-5-oxopentanoic acid→Methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate

    Precursor

    (R)-methyl 3-((tert-butyldimethylsilyl)oxy)-6-chloro-5-oxohexanoate
    (R)-3-((tert-Butyldimethylsilyl)oxy)-5-methoxy-5-oxopentanoic acid
    Triphenylphosphine
    methyl triphenylphosphonium bromide

    Downstream Product

    methyl (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
    Rosuvastatin
    7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
    7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester

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