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Picture of METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE

METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE

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Origin: China

Cas No: 486460-08-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 486460-08-6 Formula: C15H18F3NO4 Molecular Weight: 333.30300

    Basic Info

    Chemical Name METHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE
    Synonyms

    CAS No. 486460-08-6
    Molecular Formula C15H18F3NO4
    Molecular Weight 333.30300
    PSA 64.63000
    LogP 3.10360

    Synthesis Route

    tert-butoxycarbonyl anhydride+(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazineMETHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE
    methyl (R)-2-amino-3-(2,4,5-trifluorophenyl)propanoate+tert-butoxycarbonyl anhydrideMETHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE
    tert-butoxycarbonyl anhydrideMETHYL (2R)-2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(2,4,5-TRIFLUOROPHENYL)PROPANOATE

    Precursor

    (Z)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)acrylate
    tert-butoxycarbonyl anhydride
    (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine
    methyl (R)-2-amino-3-(2,4,5-trifluorophenyl)propanoate

    Downstream Product

    sitagliptin
    Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid
    (R)-2-((tert-Butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid

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