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Methotrexate disodium salt

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Origin: China

Cas No: 7413-34-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 7413-34-5 Formula: C20H20N8Na2O5 Molecular Weight: 498.40300

Basic Info

Chemical Name	Methotrexate disodium salt
Synonyms	METHOTREXATE DISODIUM; 4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt; mtxdisodium; Methotrexate Disodium Salt Solution; amethopterinsodium; METHOTREXATUM; disodiummethotrexate; sodium methotrexate; N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamatic acid disodium; l-(+)-isodiumsal;
CAS No.	7413-34-5
Molecular Formula	C20H20N8Na2O5
Molecular Weight	498.40300
PSA	216.20000
LogP	-0.84770

Properties

Storage Condition	0-6ºC

Safety Info

HS Code	2933990090

Synthesis Route

dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate→Methotrexate disodium salt
Methotrexate→Methotrexate disodium salt

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	284 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	TDLo - Lowest published toxic dose	Rodent - mouse	120 mg/kg,male 60 day(s) pre-mating	1.Reproductive-Paternal Effects-testes, epididymis, sperm duct 2.Reproductive-Fertility-male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)