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L-Menthyl glyoxylate hydrate

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Origin: China

Cas No: 111969-64-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    111969-64-3
    Other Names:
    (1S)-(+)-Menthyl glyoxylate hydrate
    MF:
    C12H22O4
    EINECS No.:
    111969-64-3
    Place of Origin:
    Shandong, China
    Type:
    Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates
    Purity:
    ≥99%
    Brand Name:
    FinerChem
    Model Number:
    111969-64-3
    Application:
    Pharmaceutical/Lamivudine intermediate
    Appearance:
    White powder
    Product Name:
    L-Menthyl glyoxylate hydrate
    CAS:
    111969-64-3
    Boiling point:
    320

    Packaging&Delivery

    Packaging Details
    Aluminium foil bag for within 10kg, 25kg/Fiber drum, 25kg/kraft bag
    Port
    SHANGHAI, QINGDAO , BEIJING, SHENZHEN , DALIAN
    Lead Time:
    Quantity(Kilograms)1 - 500>500
    Est. Time(days)4To be negotiated

    Products Description

    Product Name
    L-Menthyl glyoxylate hydrate
    CAS No.
    111969-64-3
    Appearance
    White powder
    Assay
    ≥99%
    Capacity
    2000mt/year
    Min.packing
    1gram
    Application
    Pharmaceutical/Lamivudine intermediate
    Standard
    Export 
    Brand
    Finerchem 


    More information

    Synonyms: (1S)-(+)-Menthyl glyoxylate hydrate 
    Molecular Formula: C12H22O4 
    Molecular Weight: 230.30 
    CAS Registry Number: 111969-64-3 
    Boiling point: 320 ºC 
    Flash point: 113 ºC

  • Property

    CAS No.: 111969-64-3 Formula: C12H22O4 Molecular Weight: 230.30100

    Description

    L-Menthyl 2,2-Dihydroxyacetate is used as a reagent in the synthesis of Lamivudine; a potent nucleoside reverse transcriptase inhibitor used for the treatment of chronic hepatitis B. L-Menthyl 2,2-Dihydroxyacetate is also used as a reagent in the synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one, a key intermediate for the preparation of penem and carbapenem antibiotics.

    Basic Info

    Chemical Name L-Menthyl glyoxylate hydrate
    Synonyms

    2,2-Dihydroxyacetic Acid (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl Ester;
    Glyoxylic acid (1S)-menthyl ester hydrate;
    L-Menthyl Glyoxylate Hydrate;
    L-Menthyl glyoxylate monohydrate;
    2,2-Dihydroxyacetic acid (-)-menthyl ester;
    (1R)-(-)-Menthyl glyoxylate monohydrate;
    Acetic acid, 2,2-dihydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester;
    2,2-Dihydroxyacetic acid, (-)-menthyl ester;
    (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2,2-Dihydroxyacetate;
    L-menthyl glyoxylate;
    L-MGH;
    Acetic acid, dihydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester, [1R-(1α,2β,5α)]-;
    (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl dihydroxy-acetate;
    (-)-menthyl glyoxylate hydrate;
    L-MENTHYL 2,2-DIHYDROXYACETATE;
    Acetic acid, dihydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester;
    (-)-Menthyl 2,2-Dihydroxyacetate;

    CAS No. 111969-64-3
    Molecular Formula C12H22O4
    Molecular Weight 230.30100
    PSA 66.76000
    LogP 1.30110

    Properties

    Density 1.09
    Boiling Point 320 ºC
    Melting Point 80-81 °C
    Flash Point 113 ºC
    Refractive Index 1.487
    Vapor Pressure 2.74E-05mmHg at 25°C

    Safety Info

    Hazard Class 9
    Safety Statements S61
    Packing Group III
    RIDADR UN 3077
    Risk Statements R51/53
    Hazard Codes Xn; N

    Synthesis Route

    (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-chloro-2-oxoacetate→(1R)-(-)-Menthyl glyoxylate+L-Menthyl glyoxylate hydrate
    L-Menthol→L-Menthyl glyoxylate hydrate
    (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-chloro-2-oxoacetate→L-Menthyl glyoxylate hydrate

    Precursor

    (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-chloro-2-oxoacetate
    L-Menthol

    Downstream Product

    (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester
    (1R)-(-)-Menthyl glyoxylate
    (2R,5S)-L-Methyl-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
    [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2R,5R)-5-acetyloxy-1,3-oxathiolane-2-carboxylate

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