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Histamine dihydrochloride

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Origin: China

Cas No: 56-92-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    56-92-8
    Other Names:
    Histamine dihydrochloride
    MF:
    C5H11Cl2N3
    EINECS No.:
    200-298-4
    Type:
    Pharmaceutical Intermediates, Syntheses Material Intermediates
    Purity:
    98%
    Application:
    API
    Appearance:
    white to off-white
    Test Method:
    HPLC Test
    Other Country:
    Shaanxi

    Packaging&Delivery

    Packaging Details
    Packing:1kg/bad,25kgs/drum Two plasti-bags inside and Paper-drums or as customer's requirements
    Port
    Major ports in China
    Lead Time:
    Quantity(Grams)1 - 10000>10000
    Est. Time(days)1To be negotiated

  • Property

    CAS No.: 56-92-8 Formula: C5H11Cl2N3 Molecular Weight: 184.06700

    Description

    Histamine dihydrochloride (INN, trade name Ceplene) is a salt of histamine which is used as a drug for the prevention of relapse in patients diagnosed with acute myeloid leukemia (AML).
    It is an FDA approved active ingredient for topical analgesic use and is available in such products as Australian Dream Cream, which is used for the temporary relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, bruises, sprains, and strains.

    Basic Info

    Chemical Name Histamine dihydrochloride
    Synonyms

    histamine*2HCl;
    histaMine (HCl)2;
    HISTAMINEHYDROCHLORIDE;
    2-(1H-imidazol-4-yl)ethanamine hydrochloride;
    2-(1H-Imidazol-4-yl)ethanamine dihydrochloride;
    HISTAMINE DIHCL;
    hystamine dihydrochloride;
    1H-Imidazole-4-ethanamine, dihydrochloride;
    histaminedichloride;

    CAS No. 56-92-8
    Molecular Formula C5H11Cl2N3
    Molecular Weight 184.06700
    PSA 54.70000
    LogP 2.21520

    Properties

    Appearance & Physical State white powder
    Density 1.14 g/cm3
    Boiling Point 331ºC at 760 mmHg
    Melting Point 249-252ºC
    Flash Point 180.3ºC
    Water Solubility SOLUBLE
    Stability Stable. Incompatible with strong oxidizing agents.
    Storage Condition 2-8ºC

    Safety Info

    RTECS MS1575000
    Safety Statements S22-S37
    HS Code 2933290090
    WGK Germany 2
    RIDADR UN 3335
    Risk Statements R42
    Hazard Codes Xi
    Symbol GHS07, GHS08
    Caution Statement P261; P280; P305 + P351 + P338; P342 + P311
    Signal Word Danger
    Hazard Declaration H315; H317; H319; H334; H335

    Synthesis Route

    4-(2-azidoethyl)-1-tosyl-1H-imidazole→Histamine dihydrochloride
    2-(1H-Imidazol-4-yl)Ethanol→Histamine dihydrochloride
    1H-Imidazole-4-ethanamine, monohydrochloride→Histamine dihydrochloride

    Precursor

    2-(1H-Imidazol-4-yl)Ethanol
    NO-bis-p-tolylsulphonylhistaminol
    1H-Imidazole-4-ethanamine, monohydrochloride
    4-(2-azidoethyl)-1-tosyl-1H-imidazole

    Downstream Product

    7,8-dihydro-6H-imidazo[1,5-c]pyrimidin-5-one
    histamine
    4-pyridin-3-yl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
    4-pyridin-4-yl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

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