flutamide

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Origin: China

Cas No: 13311-84-7

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CAS No.: 13311-84-7 Formula: C11H11F3N2O3 Molecular Weight: 276.21200

Description

Flutamide is a nonsteroidal antiandrogen drug; antineoplastic (hormonal).

Basic Info

Chemical Name	flutamide
Synonyms	4'-Nitro-3'-(trifluoromethyl)isobutyranilide; Eulexin; Flutamidum; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide; Drogenil; Niftholide; [14C]-Flutamide; NFBA; Flutamide; 4'-nitro-3'-trifluoromethylisobutyranilide; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide; Niftolide; niftolid; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide,Flutamide; 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; Flutamida;
CAS No.	13311-84-7
Molecular Formula	C11H11F3N2O3
Molecular Weight	276.21200
PSA	74.92000
LogP	3.80430

Properties

Appearance & Physical State	Light Yellow Solid
Density	1.372 g/cm3
Boiling Point	400.3ºC at 760 mmHg
Melting Point	112ºC
Flash Point	195.9ºC
Refractive Index	1.477
Stability	Stable at normal temperatures and pressures.

Safety Info

Synthesis Route

3'-Trifluoromethylisobutyranilide→flutamide
3-Aminobenzotrifluoride→flutamide
(trifluoromethyl)benzene→flutamide

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - man	310 mg/kg/31D-I	1.Behavioral-euphoria
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	787 mg/kg	1.Kidney, Ureter, Bladder-hematuria 2.Kidney, Ureter, Bladder-incontinence 3.Nutritional and Gross Metabolic-body temperature decrease
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	289 mg/kg	1.Behavioral-altered sleep time (including change in righting reflex) 2.Lungs, Thorax, or Respiration-cyanosis 3.Nutritional and Gross Metabolic-body temperature decrease