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Febrifugine

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Origin: China

Cas No: 24159-07-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property
CAS No.: 24159-07-7 Formula: C16H19N3O3 Molecular Weight: 301.34000

Description
Febrifugine is a quinazolinone alkaloid first isolated from the Chinese herb Dichroa febrifuga, but also found in the garden plant Hydrangea. Laboratory synthesis of febrifugine determined that the originally reported stereochemistry was incorrect.
Febrifugine has antimalarial properties and the halogenated derivative halofuginone is used in veterinary medicine as a coccidiostat. Halofuginone is specifically shown to be an effective drug in malaria, cancer, fibrosis and inflammatory disease.

Basic Info

Chemical Name Febrifugine

Synonyms
febrifungine;

CAS No. 24159-07-7

Molecular Formula C16H19N3O3

Molecular Weight 301.34000

PSA 84.22000

LogP 0.79740

Properties

Density 1.39 g/cm3

Boiling Point 508.2ºC at 760 mmHg

Flash Point 261.1ºC

Refractive Index 1.673

Vapor Pressure 3.76E-11mmHg at 25°C

Safety Info

HS Code 2933990090

Synthesis Route
(3aR,7aS)-benzyl 2-hydroxy-2-((4-oxoquinazolin-3(4H)-yl)methyl)hexahydrofuro[3,2-b]pyridine-4(2H)-carboxylate→Febrifugine
benzyl (2R,3S)-3-(benzyloxy)-2-(2-hydroxy-3-(4-oxoquinazolin-3(4H)-yl)propyl)piperidine-1-carboxylate→Febrifugine
(2R,3S)-3-benzyloxy-2-[2-oxo-3-(4-oxoquinazolin-3(4H)-yl)propyl]piperidine-1-carboxylic acid benzyl ester→Febrifugine

Precursor
(3aR,7aS)-benzyl 2-hydroxy-2-((4-oxoquinazolin-3(4H)-yl)methyl)hexahydrofuro[3,2-b]pyridine-4(2H)-carboxylate
(3S)-trans-O-acetyl-N-benzyloxycarbonyl-febrifugine
(2R,3S)-3-benzyloxy-2-[2-oxo-3-(4-oxoquinazolin-3(4H)-yl)propyl]piperidine-1-carboxylic acid benzyl ester
(+)-isofebrifugine