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FASUDIL

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Origin: China

Cas No: 103745-39-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 103745-39-7 Formula: C14H19Cl2N3O2S Molecular Weight: 364.29100

    Description

    A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).

    Basic Info

    Chemical Name FASUDIL
    Synonyms

    Fasudilum [inn-latin];
    H-1077 dihydrochloride;
    hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine;
    1-(5-isoquinolinesulphonyl)-homopiperazine;
    1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine,Dihydrochloride;
    1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE;
    HA 1077,DIHYDROCHLORIDE;
    HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE;
    at877;
    Fasudilum;

    CAS No. 103745-39-7
    Molecular Formula C14H19Cl2N3O2S
    Molecular Weight 364.29100
    PSA 70.68000
    LogP 4.17030

    Properties

    Appearance & Physical State White crystalline solid
    Density 1.289g/cm3
    Boiling Point 506.2ºC at 760mmHg
    Flash Point 259.9ºC
    Vapor Pressure 2.55E-12mmHg at 25°C

    Safety Info

    RTECS HM4031166
    HS Code 2933990090
    WGK Germany 3

    Synthesis Route

    Homopiperazine+Isoquinoline-5-sulfonyl chlorideFASUDIL
    Homopiperazine+Isoquinoline-5-sulfonyl chloride hydrochlorideFASUDIL

    Precursor

    Homopiperazine
    Isoquinoline-5-sulfonyl chloride hydrochloride
    Isoquinoline-5-sulfonyl chloride

    Downstream Product

    Fasudil Hydrochloride

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