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ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate

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начало: Китай

Кас Но: 56995-20-1

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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CAS No.: 56995-20-1 Formula: C15H17FN4O2 Molecular Weight: 304.31900

Description

Flupirtine is an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non-opioid, non-NSAID, non-steroidal centrally acting analgesic. In 2010 the chemically related drug (the difference being that the pyridine group in flupirtine is replaced with a phenyl group) retigabine (INN; ezogabine [USAN]) was approved by the FDA as an anticonvulsant for the treatment of refractory partial-onset seizures in treatment-experienced patients. Retigabine also works by opening the neuronal KCNQ/Kv7 potassium channel, just like flupirtine.

Basic Info

Chemical Name	ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate
Synonyms	Flupirtine; Effirma;
CAS No.	56995-20-1
Molecular Formula	C15H17FN4O2
Molecular Weight	304.31900
PSA	89.27000
LogP	3.71060

Properties

Density	1.35g/cm3
Boiling Point	434.9ºC at 760mmHg
Melting Point	115 - 116ºC
Flash Point	216.8ºC
Refractive Index	1.661

Synthesis Route

2,3-Diaminopyridine→ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate
spiro[1,3-dihydroimidazo[4,5-b]pyridine-2,1'-cyclohexane]→ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate
→ethyl N-[2-amino-6-[(4-fluorophenyl)methylamino]pyridin-3-yl]carbamate

Precursor

spiro[1,3-dihydroimidazo[4,5-b]pyridine-2,1'-cyclohexane]

2,3-Diaminopyridine
Ethyl chloroformate

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