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DMT-2′O-TBDMS-rC(ac) Phosphoramidite

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Origin: China

Cas No: 121058-88-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 121058-88-6 Formula: C47H64N5O9PSi Molecular Weight: 902.09800

Basic Info

Chemical Name	DMT-2′O-TBDMS-rC(ac) Phosphoramidite
Synonyms	Ac-rC Phosphoramidite; Ac-rCPhosphoramidite; N-[1-[(2S,3S,4S,5S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide;
CAS No.	121058-88-6
Molecular Formula	C47H64N5O9PSi
Molecular Weight	902.09800
PSA	169.22000
LogP	9.24958

Synthesis Route

2-cyanoethyl N,N- diisopropylchlorophosphoramidite+N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide→DMT-2′O-TBDMS-rC(ac) Phosphoramidite
4,4'-Dimethoxytrityl chloride→DMT-2′O-TBDMS-rC(ac) Phosphoramidite
5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine→DMT-2′O-TBDMS-rC(ac) Phosphoramidite

Precursor

tert-butyldimethylsilyl chloride
N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
2-cyanoethyl N,N- diisopropylchlorophosphoramidite
5'-O-(4,4'-Dimethoxytrityl)-N4-acetyl-2'-deoxycytidine

Downstream Product

N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

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