Dimethyliodoarsine

Dimethyliodoarsine is a dimethylated metabolite of Arsenic Trioxide that acts as a more potent growth inhibitor and apoptotic inducer in NB4 cells, an APL cell line. Dimethyliodoarsine is an arsenite metabolite in wild type CHO cells and in cells deficient in excision repair cross-complementing 1 and 2. Dimethyliodoarsine is also an inhibitor of Thioredoxin reductase, an enzyme involved in the response of the cell to oxidative stress.