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D-Mannoheptulose

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Origin: China

Cas No: 3615-44-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 3615-44-9 Formula: C7H14O7 Molecular Weight: 210.18200

Description

Mannoheptulose is a hexokinase inhibitor. It is a heptose, a monosaccharide with seven carbon atoms. By blocking the enzyme hexokinase, it prevents glucose phosphorylation. As a result, the breakdown of glucose is inhibited. It is found as D-mannoheptulose in avocados.
Mannoheptulose has been reported to inhibit insulin secretion from pancreas. This inhibition occurs because when mannoheptulose is present the glycolysis is inhibited (because there is no production of glucose-6-P) therefore no increase in ATP concentration which is required to close the KATP channel in the beta cells of the pancreas causing a diminution of calcium entry and insulin secretion.

Basic Info

Chemical Name	D-Mannoheptulose
Synonyms	D-MANNOHEPTULOSE; D-Manno-2-heptulose;
CAS No.	3615-44-9
Molecular Formula	C7H14O7
Molecular Weight	210.18200
PSA	130.61000
LogP	-3.85890

Properties

Density	1.645 g/cm3
Boiling Point	628ºC at 760 mmHg
Melting Point	151-152ºC
Flash Point	347.6ºC
Refractive Index	1.636

Safety Info

HS Code	2914400090

Synthesis Route

D-GLYCERO-L-MANNO-HEPTOSE→D-Mannoheptulose
2-Nitroethanol+aldehydo-D-arabinose→D-Mannoheptulose+D-GLUCOHEPTULOSE
2-Nitroethanol+aldehydo-D-arabinose→D-Mannoheptulose+D-GLUCOHEPTULOSE

Precursor

Sodium methoxide
aldehydo-D-arabinose
D-GLYCERO-L-MANNO-HEPTOSE
2-Nitroethanol

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