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cuscohygrine

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Origin: China

Cas No: 454-14-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 454-14-8 Formula: C13H24N2O Molecular Weight: 224.34200

Description

Cuscohygrine is a pyrrolidine alkaloid found in coca. It can also be extracted from plants of the family Solanaceae as well, including Atropa belladonna (deadly nightshade), Datura inoxia and Datura stramonium (jimson weed). Cuscohygrine usually occurs along with other, more potent alkaloids such as atropine or cocaine.
Cuscohygrine, along with the related metabolite hygrine, was first isolated by Carl Liebermann in 1889 as an alkaloid accompanying cocaine in coca leaves (also known as Cusco-leaves).
Cuscohygrine is an oil that can be distilled without decomposition only in vacuum. It is soluble in water. It also forms a crystalline trihydrate which melts at 40–41°C.

Basic Info

Chemical Name	cuscohygrine
Synonyms	2-Propanone, 1,3-bis(1-methyl-2-pyrrolidinyl)-, (R,S)-; Hellaradine; Cuscohygrine; Cuskhygrine;
CAS No.	454-14-8
Molecular Formula	C13H24N2O
Molecular Weight	224.34200
PSA	23.55000
LogP	1.39990

Properties

Density	0.989 g/cm3
Boiling Point	312.4ºC at 760 mmHg
Refractive Index	1.488
Stability	Solutions are unstable.
Storage Condition	-20ºC Freezer
Vapor Pressure	0.000531mmHg at 25°C

Safety Info

HS Code	2933990090

Synthesis Route

1,3-bis-(1-methyl-pyrrol-2-yl)-acetone→cuscohygrine
N-methylpyrrolidin-2-one+1,3-Acetonedicarboxylic acid→cuscohygrine
1,3-Acetonedicarboxylic acid+4-methylamino-butyraldehyde→cuscohygrine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	DB-1	-	1650.	temperature ramp
Capillary	OV-1	-	1650.	temperature ramp
Capillary	DB-1	-	1650.	temperature ramp
Capillary	OV-1	-	1650.	custom temperature program