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cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate

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Origin: China

Cas No: 61397-56-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 61397-56-6 Formula: C18H15BrCl2O4 Molecular Weight: 446.11900

Description

cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate is an intermediate in the preparation of antifungal agents such as Ketoconazole, Itraconazole and Terconazole.

Basic Info

Chemical Name	cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate
Synonyms	cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate;
CAS No.	61397-56-6
Molecular Formula	C18H15BrCl2O4
Molecular Weight	446.11900
PSA	44.76000
LogP	4.81350

Properties

Density	1.512g/cm3
Boiling Point	517ºC at 760 mmHg
Flash Point	266.5ºC
Refractive Index	1.59

Synthesis Route

[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methanol+Benzoyl chloride→cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate+cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate
Sodium benzoate+(+/-)-2-(bromomethyl)-4-(chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane→cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate+cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate
(2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol→cis-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate

Precursor

Benzoyl chloride
(+/-)-2-(bromomethyl)-4-(chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane
[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methanol
(2-(2,4-dichlorophenyl)-2-methyl-1,3-dioxolan-4-yl)methanol

Downstream Product

KETOCONAZOLE INTERMEDIATE
cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate
Terconazole

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