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Origin: China

Cas No: 17397-89-6

Specification: 99%min

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    CAS No.: 17397-89-6 Formula: C12H17NO3 Molecular Weight: 223.26800


    Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA. Inhibition involves covalent thioacylation that permanently inactivates the enzymes. These two behaviors may increase the availability of energy in the form of ATP, perhaps sensed by AMPK, in the hypothalamus.
    In sterol synthesis, cerulenin inhibits HMG-CoA synthetase activity. It was also reported that cerulenin specifically inhibited fatty acid biosynthesis in Saccharomyces cerevisiae without having an effect on sterol formation. But in general conclusion, cerulenin has inhibitory effects on sterol synthesis.
    Cerulenin causes a dose-dependent decrease in HER2/neu protein levels in breast cancer cells, from 14% at 1.25 to 78% at 10 milligrams per liter, and targeting of fatty acid synthase by related drugs has been suggested as a possible treatment. Antiproliferative and pro-apoptotic effects have been shown in colon cells as well. At an intraperitoneal dose of 30 milligrams per kilogram, it has been shown to inhibit feeding and induce dramatic weight loss in mice by a mechanism similar to, but independent or downstream of, leptin signaling. It is found naturally in the industrial strain Cephalosporium caerulens (Sarocladium oryzae, the sheath rot pathogen of rice).

    Basic Info

    Chemical Name Cerulenin

    7,10-Dodecadienamide, 2,3-epoxy-4-oxo-, (2R,3S)-;
    caerulein A;

    CAS No. 17397-89-6
    Molecular Formula C12H17NO3
    Molecular Weight 223.26800
    PSA 72.69000
    LogP 1.81110


    Appearance & Physical State White to off-white powder.
    Density 1.134 g/cm3
    Boiling Point 456.1ºC at 760 mmHg
    Melting Point 93.5℃
    Flash Point 241.1ºC
    Refractive Index 1.529
    Soluble acetone: 20 mg/mL, clear, colorless to yellow
    Storage Condition -20ºC
    Vapor Pressure 1.66E-08mmHg at 25°C

    Safety Info

    Risk Statements R22
    Hazard Codes Xn

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