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cefotaxime

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Origin: China

Cas No: 63527-52-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
63527-52-6
MF:
C16H17N5O7S2, C16H17N5O7S2
EINECS No.:
264-299-1
Place of Origin:
ShanDong China
Type:
Antibiotic and Antimicrobial Agents
Grade Standard:
Medicine Grade
Brand Name:
Natural Micron Pharm Tech, Natural Micron Pharm Tech
Model Number:
131741-08-7
Purity:
99%, 99%
Product Name:
Cefotaxime
CAS:
63527-52-6
Appearance:
white Powder
MW:
455.46548
Test Method:
HPLC
EINECS:
264-299-1
Packaging&Delivery
Packaging Details
PACKING:Aluminium Foil Bags,Cartons,Drums
Port
Qing Dao Port/Shang Hai port
Lead Time:
Quantity(Kilograms) 1 - 10 >10
Est. Time(days) 5 To be negotiated

Property

CAS No.: 63527-52-6 Formula: C16H17N5O7S2 Molecular Weight: 455.46500

Description

Cefotaxime (INN) is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, cefotaxime is a broad-spectrum antibiotic with activity against numerous gram-positive and gram-negative bacteria. Developed by Hoechst-Roussel Pharmaceuticals in the late 1980s, it was among the first third-generation ("extended spectrum") cephalosporins and the first of its class to become available in the United States. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Basic Info

Chemical Name	cefotaxime
Synonyms	Cefotaxime; Zariviz; Cefabol; Cefotaxima acid; Cephotaxime;
CAS No.	63527-52-6
Molecular Formula	C16H17N5O7S2
Molecular Weight	455.46500
PSA	227.05000
LogP	0.28750

Properties

Appearance & Physical State	white power
Density	1.8 g/cm3
Refractive Index	1.778

Safety Info

HS Code	3003201100

Synthesis Route

(6R,7R)-3-(acetyloxymethyl)-7-[[(2E)-2-[2-[(2-chloroacetyl)amino]-1,3-thiazol-4-yl]-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid→cefotaxime
(6R,7R)-3-(acetoxymethyl)-7-(4-chloro-2-(methoxyimino)-3-oxobutanamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid+thiourea→cefotaxime
S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate+7-Aminocephalosporanic acid→cefotaxime+2-Mercaptobenzothiazole

Precursor

thiourea
7-Aminocephalosporanic acid
S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate
(6R,7R)-3-(acetoxymethyl)-7-(4-chloro-2-(methoxyimino)-3-oxobutanamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Downstream Product

cefpodoxime proxetil
Cefpirome
1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-5,6,7,8-tetrahydro-quinolinium inner salt
Ceftiofur

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