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Bis-TBDMS-trans-calcipotriol

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Origin: China

Cas No: 112849-27-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 112849-27-1 Formula: C39H68O3Si2 Molecular Weight: 641.12600

Description

Protected trans-Calcipotriol, a vitamin D analog.

Basic Info

Chemical Name	Bis-TBDMS-trans-calcipotriol
Synonyms	Trans-Calcipotriol-bis-TBDMS-ether;
CAS No.	112849-27-1
Molecular Formula	C39H68O3Si2
Molecular Weight	641.12600
PSA	38.69000
LogP	11.14960

Properties

Density	0.988 g/cm3
Boiling Point	333.713ºC
Flash Point	333.713ºC
Refractive Index	1.515

Synthesis Route

(1S,3R,3'R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene→Bis-TBDMS-trans-calcipotriol
(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one→(1S,3R,3'R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene+Bis-TBDMS-trans-calcipotriol
Cyclopropyl methyl ketone→Bis-TBDMS-trans-calcipotriol

Precursor

tert-butyldimethylsilyl chloride
(1S,3R,3'R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(E),7(E),10(19)-triene
(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one
Cyclopropyl methyl ketone

Downstream Product

(E,1S,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-1-cyclopropylpent-2-en-1-ol
calcipotriol

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