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atazanavir

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Origin: China

Cas No: 198904-31-3

Specification: 99%min

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Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 198904-31-3 Formula: C38H52N6O7 Molecular Weight: 704.85500

    Description

    Atazanavir, sold under the trade name Reyataz, is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).
    Atazanavir is distinguished from other PIs in that it can be given once-daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications.
    The U.S. Food and Drug Administration (FDA) approved atazanavir on June 20, 2003. Atazanavir is the first PI approved for once-daily dosing, and also appears to be less likely to cause lipodystrophy and elevated cholesterol as side effects. It may also not be cross-resistant with other PIs. When boosted with ritonavir it is equivalent in potency to lopinavir for use in salvage therapy in patients with a degree of drug resistance, although boosting with ritonavir reduces the metabolic advantages of atazanavir.
    It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

    Basic Info

    Chemical Name atazanavir
    Synonyms

    methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;
    Zrivada;
    Atazanavir;
    2aqu;
    Reyataz;
    UNII-QZU4H47A3S;
    [3H]-Atazanavir;

    CAS No. 198904-31-3
    Molecular Formula C38H52N6O7
    Molecular Weight 704.85500
    PSA 171.22000
    LogP 5.77520

    Properties

    Appearance & Physical State crystalline solid
    Density 1.178g/cm3
    Melting Point 207-209ºC
    Refractive Index 1.562

    Synthesis Route

    L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide+methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate→atazanavir
    methyl ((S)-1-(((2S,3S)-4-(2-((S)-2-amino-3,3-dimethylbutanoyl)-1-(4-(pyridin-2-yl)benzyl)hydrazinyl)-3-hydroxy-1-phenylbutan-2-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate+methyl carbonochloridate→atazanavir
    4-(2-Pyridinyl)benzaldehyde→atazanavir

    Precursor

    methyl [(2S)-3,3-dimethyl-1-({(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}amino)-1-oxobutan-2-yl]carbamate
    methyl carbonochloridate
    L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide
    4-(2-Pyridinyl)benzaldehyde

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