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acridine orange

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Origin: China

Cas No: 494-38-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 494-38-2 Formula: C17H19N3 Molecular Weight: 265.35300

    Description

    Acridine orange is an organic compound. It is used as a nucleic acid-selective fluorescent cationic dye useful for cell cycle determination. Being cell-permeable, it interacts with DNA and RNA by intercalation or electrostatic attractions respectively. When bound to DNA, it is very similar spectrally to fluorescein, with an excitation maximum at 502 nm and an emission maximum at 525nm (green). When it associates with RNA, the excitation maximum shifts to 460nm (blue) and the emission maximum shifts to 650nm (red). Acridine orange will also enter acidic compartments such as lysosomes and become protonated and sequestered. In these low pH conditions, the dye will emit orange light when excited by blue light. Thus, acridine orange can be used to identify engulfed apoptotic cells, because it will fluoresce upon engulfment. The dye is often used in epifluorescence microscopy.

    Basic Info

    Chemical Name acridine orange
    Synonyms

    3,6-Bis(dimethylamino)acridine Solvent Orange 15;
    Acridine Orange base;
    N3,N3,N6,N6-Tetramethylacridine-3,6-diamine;
    ACRIDINE ORANGE;

    CAS No. 494-38-2
    Molecular Formula C17H19N3
    Molecular Weight 265.35300
    PSA 19.37000
    LogP 3.52000

    Properties

    Appearance & Physical State BROWN POWDER
    Density 1.169 g/cm3
    Boiling Point 468.6ºC at 760 mmHg
    Melting Point 165ºC (dec.)(lit.)
    Flash Point 237.2ºC
    Refractive Index 1.71

    Safety Info

    RTECS AR7600000
    WGK Germany 3

    Synthesis Route

    2,2'-methylenebis(5-dimethylamino)aniline→acridine orange
    Oxalic acid+3-N,3-N-dimethylbenzene-1,3-diamine→acridine orange
    formic acid+3-N,3-N-dimethylbenzene-1,3-diamine→acridine orange

    Precursor

    3-N,3-N-dimethylbenzene-1,3-diamine
    formic acid
    (2S)-2-cyclohexyl-2-hydroxyacetic acid
    2,2'-methylenebis(5-dimethylamino)aniline

    Downstream Product

    2,8-BIS(DIMETHYLAMINO)-10-DODECYL-ACRIDINIUM BROMIDE
    10-(6-bromohexyl)-3-N,3-N,6-N,6-N-tetramethylacridin-10-ium-3,6-diamine,iodide
    10-OCTADECYLACRIDINE ORANGE BROMIDE
    10-[6-(2-aminoethylamino)hexyl]-3-N,3-N,6-N,6-N-tetramethylacridin-10-ium-3,6-diamine,chloride,tetrahydrochloride

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