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5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole

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Origin: China

Cas No: 53-85-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 53-85-0 Formula: C12H12Cl2N2O4 Molecular Weight: 319.14100

Description

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.

Basic Info

Chemical Name	5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
Synonyms	5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole; DRB; 5,6-Dichlorobenzimidazole Riboside; 5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside;
CAS No.	53-85-0
Molecular Formula	C12H12Cl2N2O4
Molecular Weight	319.14100
PSA	87.74000
LogP	0.95460

Properties

Appearance & Physical State	White to off-white crystalline solid.
Density	1.84 g/cm3
Boiling Point	606.2ºC at 760 mmHg
Melting Point	222-224ºC
Flash Point	320.4ºC
Refractive Index	1.749
Storage Condition	-20ºC

Safety Info

WGK Germany	3

Synthesis Route

5,6-dichloro-2-(methylthio)-1-β-D-ribofuranosylbenzimidazole→5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
5,6-dichloro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)benzimidazole→5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole
5,6-Dichlorobenzimidazole→5,6-Dichloropurine-1-β-D-ribofuanosyl-H-benzimidazole

Precursor

5,6-dichloro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)benzimidazole
5,6-Dichlorobenzimidazole
[3,4-bis(benzoyloxy)-5-chlorooxolan-2-yl]methyl benzoate
5,6-dichloro-2-(methylthio)-1-β-D-ribofuranosylbenzimidazole

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