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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Intermediates> ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
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((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate

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Origin: China

Cas No: 144163-97-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 144163-97-3 Formula: C11H8N2O5S Molecular Weight: 280.25700

    Description

    Retinovir intermediate.

    Basic Info

    Chemical Name ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
    Synonyms

    (4-nitrophenyl) 1,3-thiazol-5-ylmethyl carbonate;

    CAS No. 144163-97-3
    Molecular Formula C11H8N2O5S
    Molecular Weight 280.25700
    PSA 122.48000
    LogP 3.29010

    Properties

    Appearance & Physical State Pale-Yellow Solid
    Density 1.485
    Boiling Point 475.333ºC at 760 mmHg
    Melting Point 126-127ºC
    Flash Point 241.273ºC
    Refractive Index 1.627
    Vapor Pressure 0mmHg at 25°C

    Safety Info

    HS Code 2934100090

    Synthesis Route

    5-(Hydroxymethyl)thiazole+4-Nitrophenyl chloroformate→((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
    5-(Hydroxymethyl)thiazole+BIS(4-NITROPHENYL) CARBONATE→((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate
    4-Methylmorpholine+5-(Hydroxymethyl)thiazole→((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate

    Precursor

    5-(Hydroxymethyl)thiazole
    BIS(4-NITROPHENYL) CARBONATE
    4-Methylmorpholine
    4-Nitrophenyl chloroformate

    Downstream Product

    tert-Butyl (thiazol-5-ylmethyl) ((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)dicarbamate
    Thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate
    ritonavir

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