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5-Chlorooxindole

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Origin: China

Cas No: 17630-75-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 17630-75-0 Formula: C8H6ClNO Molecular Weight: 167.59200

Description

5-Chloro-2-oxindole is used in the preparation of novel GSK-3β inhibitors as anticancer agents.

Basic Info

Chemical Name	5-Chlorooxindole
Synonyms	5-Chloro-2-oxindole; 5-chloro-1,3-dihydroindol-2-one; 5-Chloro-2-indolinone;
CAS No.	17630-75-0
Molecular Formula	C8H6ClNO
Molecular Weight	167.59200
PSA	29.10000
LogP	1.97260

Properties

Appearance & Physical State	off-white crystalline powder
Density	1.362 g/cm3
Boiling Point	348.3ºC at 760 mmHg
Melting Point	194-197ºC
Flash Point	164.5ºC
Refractive Index	1.663
Storage Condition	Keep Cold
Vapor Pressure	0.00881mmHg at 25°C

Safety Info

Safety Statements	S24-S36/37/39-S45
HS Code	2933790090
WGK Germany	2
Risk Statements	R22; R36/37/38; R43; R62
Hazard Codes	Xn

Synthesis Route

N-methoxy-2,3-dihydro-1-indol-2-one→5-Chlorooxindole+7-Chlorooxindole
5-Chloroisatin→5-Chlorooxindole
2-(2-bromo-5-chlorophenyl)acetamide→5-Chlorooxindole

Precursor

2-(2-bromo-5-chlorophenyl)acetamide
2-(5-chloro-2-nitrophenyl)acetic acid
(5-chloro-2-nitro-phenyl)acetic acid methyl ester
5-chloro-3-diazo-1,3-dihydro-2H-indol-2-one

Downstream Product

N-benzoyl-5-chloro-2-oxo-3H-indole-1-carboxamide
5-Chloro-1,3-dihydroindole-2-thione
3,3-dibromo-5-chloro-1H-indol-2-one
tenidap

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