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Picture of 5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid

5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid

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Origin: China

Cas No: 5891-45-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 5891-45-2 Formula: C17H23NO6 Molecular Weight: 337.36800

    Description

    A protected glutamic acid for use in peptide synthesis.

    Basic Info

    Chemical Name 5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
    Synonyms

    N-[(Phenylmethoxy)carbonyl]-L-glutamic acid tert-butyl ester;
    Cbz-L-glutamic acid 1-tert-butyl ester;
    N2-(benzyloxycarbonyl)-L-glutamic acid 1-tert-butyl ester;
    (S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester;
    z-glu-otbu;

    CAS No. 5891-45-2
    Molecular Formula C17H23NO6
    Molecular Weight 337.36800
    PSA 101.93000
    LogP 2.87880

    Properties

    Density 1.197 g/cm3
    Boiling Point 522.6ºC at 760 mmHg
    Flash Point 269.9ºC
    Refractive Index 1.523
    Storage Condition 2-8ºC

    Synthesis Route

    1-tert-butyl 5-methyl (2S)-2-{[(benzyloxy)carbonyl]amino}pentanedioate5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
    tert-butyl N-benzyloxycarbonyl-L-pyroglutamate5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
    N-Cbz-L-glutamic acid5-[(2-methylpropan-2-yl)oxy]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid

    Precursor

    tert-butyl N-benzyloxycarbonyl-L-pyroglutamate
    (2S)-5-oxo-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid
    1-tert-butyl 5-methyl (2S)-2-{[(benzyloxy)carbonyl]amino}pentanedioate
    N-Cbz-L-glutamic acid

    Downstream Product

    tert-butyl (2S)-5-methylsulfonyloxy-2-(phenylmethoxycarbonylamino)pentanoate
    N-Cbz-L-proline tert-Butyl Ester
    (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid
    tert-butyl (2S)-5-hydroxy-2-(phenylmethoxycarbonylamino)pentanoate

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