Home > Chiral Compounds> 4,16-ANDROSTADIEN-3-β-OL

4,16-ANDROSTADIEN-3-β-OL

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Origin: China

Cas No: 23062-06-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 23062-06-8 Formula: C19H28O Molecular Weight: 272.42500

Description

4,16-Androstadien-3β-ol (developmental code name PH94B; tentative commercial name Aloradine or Aloradine IN) is a pherine which is under development by Pherin Pharmaceuticals, Inc. in a nasal spray formulation for the acute (p.r.n.) treatment of social anxiety disorder in women. It is also being investigated by Pherin Pharmaceuticals for the treatment of generalized anxiety disorder in women. As of 2015, it is in phase III clinical trials.
The compound lacks affinity for steroid hormone receptors and has instead been found to directly activate isolated human vomeronasal receptor cells at nanomolar concentrations (EC50 = 200 nM).
The pheromone androstenol has been found to act as a potent positive allosteric modulator of the GABAA receptor, and it has been proposed that this action may mediate its pheromone effects. It produces anxiolytic-like effects in animals. Androstadienol, androstadienone, and androstenone, all of which are also pheromones, have been found to be converted into androstenol, and as such, it may be responsible for their pheromone effects. As 4,16-androstadien-3β-ol is very closely related structurally to androstadienol (which is 5,16-androstadien-3β-ol), being a positional isomer of the steroid, the mechanism of action of 4,16-androstadien-3β-ol could similarly be potentiation of the GABAA receptor.

Basic Info

Chemical Name	4,16-ANDROSTADIEN-3-β-OL
Synonyms	Androst-5-en-4,7,17-trione; androst-5-ene-4,7,17-trione;
CAS No.	23062-06-8
Molecular Formula	C19H28O
Molecular Weight	272.42500
PSA	20.23000
LogP	4.47620