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4-Methyl-3-(trifluoromethyl)aniline

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Origin: China

Cas No: 65934-74-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 65934-74-9 Formula: C8H8F3N Molecular Weight: 175.15100

Description

5-Amino-2-methylbenzotrifluoride is used to prepare azoles as inhibitors of VEGF receptors 1 and 2 with high intestinal permeability. It can also be used to prepare curcumin analogs conjugated with antiandrogens.

Basic Info

Chemical Name	4-Methyl-3-(trifluoromethyl)aniline
Synonyms	4-methyl-3-(trifluoromethyl)aniline;
CAS No.	65934-74-9
Molecular Formula	C8H8F3N
Molecular Weight	175.15100
PSA	26.02000
LogP	3.17720

Properties

Density	1.22
Boiling Point	204ºC
Flash Point	102ºC
Refractive Index	1.49

Safety Info

Safety Statements	S26-S36
HS Code	2921430090
WGK Germany	3
RIDADR	UN 2810
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

methyl 6-hydroxynaphthalene-1-carboxylate+4-Chloro-6-(methoxymethyl)pyrimidine→4-Methyl-3-(trifluoromethyl)aniline
Trimethylboroxine+4-Bromo-3-(trifluoromethyl)aniline→4-Methyl-3-(trifluoromethyl)aniline
tetrachloromethane+p-toluidine→4-Methyl-3-(trifluoromethyl)aniline

Precursor

Trimethylboroxine
4-Bromo-3-(trifluoromethyl)aniline
methyl 6-hydroxynaphthalene-1-carboxylate
tetrachloromethane

Downstream Product

2-iodo-4-methyl-5-(trifluoromethyl)aniline
N-[4-(bromomethyl)-3-(trifluoromethyl)phenyl]-2,2,2-trifluoroacetamide
4-Methyl-3-(trifluoromethyl)benzenesulfonyl chloride
4-(morpholin-4-ylmethyl)-3-(trifluoromethyl)aniline

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