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4-Hydroxyquinazoline

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Origin: China

Cas No: 491-36-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 491-36-1 Formula: C8H6N2O Molecular Weight: 146.14600

Description

Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common.
2-Quinazolinone 4-Quinazolinone

Basic Info

Chemical Name	4-Hydroxyquinazoline
Synonyms	4-Quinazolinol; 4-HQN; Quinazolone,4; 4-oxo-3,4-dihydroquinazoline; 4-QUINAZOLINO; QUINAZOLIN-4-OL; quinazolin-4(3H)-one; 3,4-dihydroquinazolin-4-one; QUINAZOLINONE; 3H-quinazolinyl-4-one; 4(1H)-Quinazolinone; quinazoline-4(3H)-one; 4-QUINAZOLONE; Quinazolin-4-one; QUINAZOLONE;
CAS No.	491-36-1
Molecular Formula	C8H6N2O
Molecular Weight	146.14600
PSA	45.75000
LogP	0.92310

Properties

Appearance & Physical State	White Solid
Density	1.31 g/cm3
Boiling Point	303.5ºC at 760 mmHg
Melting Point	215-219ºC
Flash Point	137.3ºC
Refractive Index	1.666
Stability	Stable at room temperature in closed containers under normal storage and handling conditions.
Storage Condition	Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Info

RTECS	VA2300000
Safety Statements	S22-S26-S36/37/39
HS Code	29335995
WGK Germany	3
Risk Statements	R22; R36/37/38
Hazard Codes	Xn

Synthesis Route

Formaldehyde+2-aminobenzamide→4-Hydroxyquinazoline
Methyl anthranilate+Trimethoxymethane→4-Hydroxyquinazoline
4H-3,1-Benzoxazine-2,4(1H)-dione+Triethyl orthoformate→4-Hydroxyquinazoline

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	609 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	450 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

Formaldehyde
4H-3,1-Benzoxazine-2,4(1H)-dione
2-aminobenzamide
Methyl anthranilate

Downstream Product

2-(4-oxoquinazolin-3-yl)-N-phenylacetamide
N-(3-nitrophenyl)-2-(4-oxoquinazolin-3-yl)acetamide
2,4-diphenyl-1H-pyrrol-3-amine
2-(4-chlorophenyl)-3-(4-oxoquinazolin-3-yl)propanal

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