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4'-Hydroxypropiophenone

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Origin: China

Cas No: 70-70-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    70-70-2
    Other Names:
    4'-Hydroxypropiophenone
    MF:
    C9H10O2
    EINECS No.:
    200-743-2
    Place of Origin:
    Shandong, China
    Type:
    Pharmaceutical Intermediates, Syntheses Material Intermediates
    Purity:
    98%
    Brand Name:
    BELIEVE
    Model Number:
    70-70-2
    Application:
    Chemical intermediate
    Appearance:
    Crystalline Powder
    Product name:
    4'-Hydroxypropiophenone
    CAS:
    70-70-2
    Density:
    1.09 g/cm3 (20℃)
    Color:
    White
    Molecular Weight:
    150.17
    Boiling point:
    36-38 °C(lit.)
    Melting point:
    152-154 °C26 mm Hg(lit.)
    Package:
    25kg/bag/drum
    MOQ:
    As per customers' requirement
    Sample:
    Availiable

    Packaging&Delivery

    Packaging Details
    25kg/bag/drum
    Port
    Qingdao
    Lead Time:
    Quantity(Kilograms)1 - 1000>1000
    Est. Time(days)2To be negotiated

  • Property

    CAS No.: 70-70-2 Formula: C9H10O2 Molecular Weight: 150.17400

    Description

    Paroxypropione (INN) (brand names Frenantol, Frenormon, Hypophenon, Paroxon, Possipione, Profenone, numerous others; former developmental code name NSC-2834), also known as paroxypropiophenone (P.O.P.) or 4'-hydroxypropiophenone, is a synthetic, non-steroidal estrogen that has been used medically as an antigonadotropin in Spain and Italy.
    Paroxypropione is closely related structurally to p-hydroxybenzoic acid and parabens such as methylparaben, and also bears a close resemblance to diethylstilbestrol (which, in fact, produces paroxypropione as an active metabolite) and alkylphenols like nonylphenol, all of which are also estrogens. The drug possesses relatively low affinity for the estrogen receptor and must be given at high dosages to achieve significant estrogenic and antigonadotropic action, for instance, 0.8 to 1.6 g/day. Paroxypropione was first synthesized in 1902. Its antigonadotropic properties were discovered in 1951 and it entered clinical use shortly thereafter.; Similarly to p-hydroxybenzoic acid, paroxypropione has been found to possess antioxidant activity.
    Paroxypropione is a precursor in the chemical synthesis of diethylstilbestrol and dienestrol.

    Basic Info

    Chemical Name 4'-Hydroxypropiophenone
    Synonyms

    Paroxypropione;
    Hypostat;
    B 360;
    Mepal;
    Frenon;
    1-Propanone, 1-(4-hydroxyphenyl)-;
    4'-hydroxy-propiophenone;
    H-365;
    VANATONE;
    Paroxon;
    p-HOC6H4COEt;
    Bio-Fren;
    para-hydroxy-propiophenone;
    PHP;
    p-hydroxypropiophenone;

    CAS No. 70-70-2
    Molecular Formula C9H10O2
    Molecular Weight 150.17400
    PSA 37.30000
    LogP 1.98490

    Properties

    Appearance & Physical State white crystals
    Density 1.104 g/cm3
    Boiling Point 152-154ºC at 26 mm Hg(lit.)
    Melting Point 148-152ºC
    Flash Point 180ºC
    Refractive Index 1.542
    Water Solubility 0.34 g/l (15 ºC)

    Safety Info

    RTECS UH1925000
    Safety Statements S24/25
    HS Code 29145000
    WGK Germany 3
    Risk Statements R36/37/38
    Hazard Codes Xn; Xi

    Synthesis Route

    phenyl propanoate→2'-Hydroxypropiophenone+4'-Hydroxypropiophenone
    phenyl propanoate→2'-Hydroxypropiophenone+4'-Hydroxypropiophenone
    +phenol→2'-Hydroxypropiophenone+4'-Hydroxypropiophenone

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD - Lethal dose Rodent - rat >500 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intramuscular TDLo - Lowest published toxic dose Rodent - rabbit 1600 mg/kg,female 15-30 day(s) after conception 1.Reproductive-Specific Developmental Abnormalities-eye/ear
    2.Reproductive-Specific Developmental Abnormalities-craniofacial (including nose and tongue)
    3.Reproductive-Effects on Newborn-stillbirth

    Precursor

    Propionyl chloride
    phenyl propanoate
    4'-Methoxypropiophenone
    4'-Benzyloxypropiophenone

    Downstream Product

    4'-(Benzyloxy)-2-bromopropiophenone
    (Z)-4,4'-(hex-3-ene-3,4-diyl)diphenol
    Diethylstilbestrol
    1-[4-(6,7,8,9,10,11-hexahydrocycloocta[b]quinolin-12-yloxy)phenyl]propan-1-one

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