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4-Chloro-8-methoxyquinoline

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Origin: China

Cas No: 16778-21-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 16778-21-5 Formula: C10H8ClNO Molecular Weight: 193.63000

Description

A potent selective CRTh2(DP2) antagonist, as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.

Basic Info

Chemical Name	4-Chloro-8-methoxyquinoline
Synonyms	4-Chlor-8-methoxychinolin; 8-Methoxy-4-chloro quinoline; BB_SC-6159; 4-chloro-8-methoxy-quinoline;
CAS No.	16778-21-5
Molecular Formula	C10H8ClNO
Molecular Weight	193.63000
PSA	22.12000
LogP	2.89680

Properties

Density	1.267g/cm3
Boiling Point	299.9ºC at 760mmHg
Flash Point	135.2ºC
Refractive Index	1.621
Vapor Pressure	0.00207mmHg at 25°C

Safety Info

HS Code	2933499090
Hazard Declaration	H302; H318
Symbol	GHS05, GHS07
Caution Statement	P280; P305 + P351 + P338
Signal Word	Danger

Synthesis Route

8-methoxy-1H-quinolin-4-one→4-Chloro-8-methoxyquinoline
8-methoxy-4-oxo-1H-quinoline-3-carboxylic acid→4-Chloro-8-methoxyquinoline
Ethyl 4-hydroxy-8-methoxyquinoline-3-carboxylate→4-Chloro-8-methoxyquinoline

Precursor

8-methoxy-4-oxo-1H-quinoline-3-carboxylic acid
8-methoxy-1H-quinolin-4-one
Ethyl 4-hydroxy-8-methoxyquinoline-3-carboxylate

Downstream Product

7-fluoro-4-(4-diethylamino-1-methylbutylamino)quinoline
8-methoxy-N-(2-methylphenyl)quinolin-4-amine
4-Chloroquinolin-8-ol

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