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4-Chloro-3-(trifluoromethyl)phenyl isocyanate

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Origin: China

Cas No: 327-78-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    327-78-6
    Other Names:
    3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE
    MF:
    C8H3ClF3NO
    Place of Origin:
    Jiangsu, China
    Type:
    Pharmaceutical Intermediates, Syntheses Material Intermediates
    Purity:
    >99%
    Brand Name:
    KPRX
    Model Number:
    CAS 220000-87-3
    Application:
    Organic synthesis, pharmaceutical intermediate
    Appearance:
    off-white crystalline solid
    Product name:
    High quality 327-78-6 with best price
    Name:
    4-Chloro-3-(trifluoromethyl)phenyl isocyanate
    Apperance:
    White Crystalline Solid
    Use:
    Sorafenib intermediate

    Packaging&Delivery

    Packaging Details
    20kg/carton
    Pallet can be avialable for bulk order.
    Port
    Shanghai any port of China
    Lead Time:
    Quantity(Kilograms)1 - 1000>1000
    Est. Time(days)15To be negotiated

  • Property

    CAS No.: 327-78-6 Formula: C8H3ClF3NO Molecular Weight: 221.56400

    Description

    4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used as a reagent to synthesize pyrimidinylaminobenzene derivatives, compounds that have antiproliferative activity against melanoma cell lines. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is also used to synthesize α-thymidine analogues that act as antimalarial agents.

    Basic Info

    Chemical Name 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
    Synonyms

    4-Chloro-3-(trifluoromethyl)phenyl Isocyanate;
    Sorafenib intermediate 3;
    Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester;
    1-chloro-4-isocyanato-2-trifluoromethylbenzene;
    3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE;
    4-Cl-3CF3-phenyl isocyanate;
    1-chloro-4-isocyanato-2-(trifluoromethyl)benzene;
    4-Chloro-3-(trifluoromethyl)phenylisocyanate;

    CAS No. 327-78-6
    Molecular Formula C8H3ClF3NO
    Molecular Weight 221.56400
    PSA 29.43000
    LogP 3.32610

    Properties

    Appearance & Physical State white to yellowish low melting solid, powder or chunks
    Density 1.4 g/cm3
    Boiling Point 86-90ºC (14 mmHg)
    Melting Point 35-36ºC
    Flash Point 99ºC
    Refractive Index 1.487

    Safety Info

    Hazard Class 6.1
    Safety Statements S26-S36/37/39
    HS Code 2929109000
    WGK Germany 3
    Packing Group III
    RIDADR UN 2206
    Risk Statements R20/21/22; R36/37/38
    Hazard Codes Xn

    Synthesis Route

    bis(trichloromethyl) carbonate+5-amino-2-chlorobenzotrifluoride→4-Chloro-3-(trifluoromethyl)phenyl isocyanate
    phosgene+5-amino-2-chlorobenzotrifluoride→4-Chloro-3-(trifluoromethyl)phenyl isocyanate
    5-amino-2-chlorobenzotrifluoride+Diphosgene→4-Chloro-3-(trifluoromethyl)phenyl isocyanate

    Precursor

    5-amino-2-chlorobenzotrifluoride
    Diphosgene
    phosgene
    bis(trichloromethyl) carbonate

    Downstream Product

    1-[4-(4-nitrophenoxy)phenyl]ethanone
    4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide
    sorafenib
    flucofuron

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