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4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid

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Origem: China

Cas No: 16506-27-7

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 80 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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Especificação de produtos
Descrição do produto

Property

CAS No.: 16506-27-7 Formula: C16H21Cl2N3O2 Molecular Weight: 358.26300

Description

Bendamustine (INN, trade names Treakisym, Ribomustin, Levact and Treanda; also known as SDX-105) is a nitrogen mustard used in the treatment of chronic lymphocytic leukemia and lymphomas. It belongs to the family of drugs called alkylating agents. It is also being studied for the treatment of sarcoma. It is also being investigated in phase II trials for the non-cancer treatment of AL amyloidosis.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.

Basic Info

Chemical Name	4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
Synonyms	Treanda (TN); Bendamustina [Spanish]; 4-{5-[bis(2-chloroethyl)amino]-1-methyl-2-benzimidazolyl} butyric acid; 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoic acid; Bendamustine (INN); Bendamustin; 4-<1-Methyl-5-<bis(2-chlorethyl)amino>benzimidazolyl-(2)>butansaeure; Bendamustinum [Latin]; UNII-9266D9P3PQ; 4-{5-[bis-(2-chloro-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid; SDX 105;
CAS No.	16506-27-7
Molecular Formula	C16H21Cl2N3O2
Molecular Weight	358.26300
PSA	58.36000
LogP	3.26460

Properties

Density	1.31 g/cm3
Boiling Point	585.2ºC at 760 mmHg
Refractive Index	1.599
Vapor Pressure	1.55E-14mmHg at 25°C

Safety Info

HS Code	2933990090

Synthesis Route

[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic acid ethyl ester→4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
bendamustine HCL→4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid
ethyl 4-(5-amino-1-methylbenzimidazol-2-yl)butanoate→4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid

Precursor

2-Fluoro-5-nitroaniline
bendamustine HCL
oxane-2,6-dione
[1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic acid ethyl ester

Downstream Product

Methyl 4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2- yl}butanoate

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