Welcome to GlobalChemMall

ALL CATEGORIES
Categories
0
Wishlist
Home > Organophosphorus Compounds> 4-[(2E)-3-Phosphono-2-propen-1-yl]-2-piperazinecarboxylic acid
Picture of 4-[(2E)-3-Phosphono-2-propen-1-yl]-2-piperazinecarboxylic acid

4-[(2E)-3-Phosphono-2-propen-1-yl]-2-piperazinecarboxylic acid

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 137424-80-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

  • Products Specification
  • Product Description

  • Property

    CAS No.: 137424-80-7 Formula: C8H15N2O5P Molecular Weight: 250.18900

    Description

    Midafotel (CPPene; SDZ EAA 494) is a potent, competitive antagonist at the NMDA receptor. It was originally designed as a potential therapy for excitotoxicity, epilepsy or neuropathic pain. It looked very promising in in vitro trials proving to be a potent competitive antagonist at the NMDA without affecting other receptors. Research continued through to in vivo cat studies where it proved to limit damage after occluding the middle cerebral artery, leading to ischaemia. It also blocked photosensitive epilepsies in baboons.
    CPPene had a pharmacokinetic profile suitable for progressing to clinical trials, as it has no toxic by products, is excreted exclusively via the renal system, and remains unchanged in the brain.
    However, CPPene was removed from clinical trials, as it provided no suitable neuronal protection or beneficial treatment for epilepsy, and had side effects which led to many patients withdrawing from trials. A possible explanation for its lack of efficacy in trials is the relatively short therapeutic time window following ischaemic damage and the fact that a small amount of glutamate helps neuronal survival. It is also believed that some "pro-survival" genes are activated by NMDA receptors.

    Basic Info

    Chemical Name 4-[(2E)-3-Phosphono-2-propen-1-yl]-2-piperazinecarboxylic acid
    Synonyms

    CAS No. 137424-80-7
    Molecular Formula C8H15N2O5P
    Molecular Weight 250.18900
    PSA 119.91000
    LogP -0.69710

    Properties

    Density 1.449g/cm3
    Boiling Point 555.6ºC at 760mmHg
    Flash Point 289.8ºC
    Refractive Index 1.555
    Vapor Pressure 8.31E-14mmHg at 25°C

Hot tags: 4-[(2e)-3-phosphono-2-propen-1-yl]-2-piperazinecarboxylic acid, China, manufacturers, suppliers, factory, wholesale, low price, high quality
Related Products
You may also like