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3',5'-cyclic GMP

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Origin: China

Cas No: 7665-99-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 7665-99-8 Formula: C10H12N5O7P Molecular Weight: 345.20500

Description

Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its most likely mechanism of action is activation of intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface.

Basic Info

Chemical Name	3',5'-cyclic GMP
Synonyms	2-Amino-6-oxo-6,9-dihydro-1H-purine 3-oxide; 3',5'-cyclic guanosine monophosphate; guanine-3-N-oxide; 2-Amino-1,7-dihydro-6H-purin-6-one 3-oxide; guanine-N3-oxide; purine-N-oxide; guanosine 3',5'-monophosphate; 2-amino-6H-purin-6-one 3-oxide; Guanin-3-N-oxid; 3',5'-cyclic monophosphate of guanosine; 2-amino-3-oxy-1,7(9)-dihydro-purin-6-one; GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE; guanosine 3',5'-cyclic monophosphate;
CAS No.	7665-99-8
Molecular Formula	C10H12N5O7P
Molecular Weight	345.20500
PSA	184.62000
LogP	-0.94290

Properties

Appearance & Physical State	powder white
Density	2.64g/cm3
Boiling Point	792.7ºC at 760 mmHg
Flash Point	433.2ºC
Refractive Index	2.064
Storage Condition	-20ºC

Safety Info

Safety Statements	S22; S26; S36
Risk Statements	R36/37/38
Hazard Codes	Xi
Symbol	GHS07
Hazard Declaration	H315; H319; H335
Signal Word	Warning
Caution Statement	P261; P305 + P351 + P338

Synthesis Route

guanosine→3',5'-cyclic GMP
GTP→3',5'-cyclic GMP
[7-(carboxymethoxy)coumarin-4-yl]methyl ester of cGMP→3',5'-cyclic GMP

Precursor

cyclic guanosine-3',5'-monophosphate [6,7-bis(carboxymethoxy)coumarin-4-yl]methyl ester
guanosine
GTP
[7-(carboxymethoxy)coumarin-4-yl]methyl ester of cGMP

Downstream Product

guanosine
guanosine 3'-monophosphate
GMP
8-bromo-3',5'-cyclic GMP

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