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(3,4-dihydroxyphenyl)acetic acid

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Origin: China

Cas No: 102-32-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    102-32-9
    Other Names:
    3,4-Dihydroxyphenylacetic acid
    MF:
    C8H8O4
    EINECS No.:
    203-024-1
    Place of Origin:
    China
    Type:
    Agrochemical Intermediates, Dyestuff Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates
    Purity:
    99%
    Brand Name:
    zeshchem
    Model Number:
    zeshchem102-32-9
    Application:
    Intermediates
    Appearance:
    white powder
    Shelf life:
    2 Years
    Molecular Weight:
    168.15
    Melting point:
    126-130 °C

    Packaging&Delivery

    Packaging Details
    100g/package, 500g/package, 1kg/package, 25kg/drum, 250kg/drum, OR according customer's request.
    Port
    Shanghai Port, China; Qingdao Port, China
    Lead Time:
    Quantity(Kilograms)1 - 1>1
    Est. Time(days)3To be negotiated

    Products Description

    Category
    Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug
    Standard
    Medical standard
    Shelf life
    2 years
    Storage
    should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
    Test Item
    Standard: USP
    Identification
    IR spectrum similar to that of RS
    HPLC retention time similar to that of RS
    Related substance
    Total impurities: NMT0.3%
    Single impurity: NMT0.1%
    Heavy metals
    NMT 10ppm
    Loss on drying
    NMT0.5%
    Residue on ignition
    NMT0.1%
    Assay
    98.5%-101.0%

  • Property

    CAS No.: 102-32-9 Formula: C8H8O4 Molecular Weight: 168.14700

    Description

    3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine.
    Dopamine can be metabolized into one of three substances. One such substance is DOPAC. Another is 3-methoxytyramine (3-MT). Both of these substances are degraded to form homovanillic acid (HVA). Both degradations involve the enzymes monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), albeit in reverse order: MAO catalyzes dopamine to DOPAC, and COMT catalyzes DOPAC to HVA; whereas COMT catalyzes dopamine to 3-MT and MAO catalyzes 3-MT to HVA. The third metabolic end-product of dopamine is norepinephrine (noradrenaline).
    DOPAC can be oxidized by hydrogen peroxide, leading to the formation of toxic metabolites which destroy dopamine storage vesicles in the substantia nigra. This may contribute to the failure of levodopa treatment of Parkinson's disease. A MAO-B inhibitor such as selegiline or rasagiline can prevent this from happening.
    Biodegradation of dopamine; It can also be found in the bark of Eucalyptus globulus.
    This product has been synthesized (52% yield) from 4-Hydroxyphenylacetic acid via aerobic biotransformation using whole cell cultures of Arthrobacter protophormiae.

    Basic Info

    Chemical Name (3,4-dihydroxyphenyl)acetic acid
    Synonyms

    Catechol-4-acetic Acid;
    Benzeneacetic acid, 3,4-dihydroxy-;
    Dopacetic acid;
    Dopac;
    4-Carboxymethylcatechol;
    4-Carboxymethylpyrocatechol;
    Pyrocatechol-4-acetic Acid;
    Homoprotocatechuate;
    Benzeneacetic acid,3,4-dihydroxy;
    3,4-dihydroxy-1-benzeneacetic acid;
    3,4-Dihydroxyphenylacetic acid;
    Dihydroxyphenylacetic acid;
    Homoprotocatechuic acid;

    CAS No. 102-32-9
    Molecular Formula C8H8O4
    Molecular Weight 168.14700
    PSA 77.76000
    LogP 0.72490

    Properties

    Appearance & Physical State Beige powder.
    Density 1.478g/cm3
    Boiling Point 418.4ºC at 760mmHg
    Melting Point 126-130ºC
    Flash Point 221ºC
    Refractive Index 1.628
    Stability Stable under normal temperatures and pressures.
    Storage Condition -20ºC
    Vapor Pressure 0mmHg at 25°C

    Safety Info

    RTECS AH0590000
    Safety Statements S26-S36
    HS Code 2918290000
    WGK Germany 3
    Risk Statements R36/37/38
    Hazard Codes Xi
    Hazard Declaration H315; H319; H335
    Signal Word Warning
    Symbol GHS07
    Caution Statement P261; P305 + P351 + P338

    Synthesis Route

    3-hydroxyphenylacetic acid→(3,4-dihydroxyphenyl)acetic acid+homogentisic acid
    3-(4-hydroxy-3-methoxyphenyl)-2-oxopropanoic acid→(3,4-dihydroxyphenyl)acetic acid+3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid
    8-O-4-DFA→ferulic acid+3-(3-hydroxyphenyl)propanoic acid

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    - DNA inhibition - 1 mmol/L -
    - Cytogenetic analysis - 100 mg/L -

    Precursor

    8-O-4-DFA
    4-hydroxyphenylacetic acid
    3-(4-hydroxy-3-methoxyphenyl)-2-oxopropanoic acid
    (3,4-Dimethoxyphenyl) Acetic Acid

    Downstream Product

    methyl 2-(1,3-benzodioxol-5-yl)acetate
    3,4-Diethoxyphenylacetic Acid
    3,4-dihydroxybenzoic acid
    (3,4-Dimethoxyphenyl) Acetic Acid

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