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Picture of 3,4-Bis(difluoromethoxy)benzaldehyde

3,4-Bis(difluoromethoxy)benzaldehyde

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Origin: China

Cas No: 127842-54-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 127842-54-0 Formula: C9H6F4O3 Molecular Weight: 238.13600

    Description

    3,4-Bis(difluoromethoxy)benzaldehyde is an impurity of the antiasthmatic drug Roflumilast. 3,4-Bis(difluoromethoxy)benzaldehyde is used in the preparation of diphenylethylene compounds as PDE4 (phosphodiesterase-4) inhibitors for treatment of cancer, CNS disorders, and inflammatory disorders.

    Basic Info

    Chemical Name 3,4-Bis(difluoromethoxy)benzaldehyde
    Synonyms

    3,4-bis(difluoromethoxy)benzaldehyde;

    CAS No. 127842-54-0
    Molecular Formula C9H6F4O3
    Molecular Weight 238.13600
    PSA 35.53000
    LogP 2.70190

    Safety Info

    HS Code 2913000090

    Synthesis Route

    sodium,2-chloro-2,2-difluoroacetate+3,4-dihydroxybenzaldehyde3,4-Bis(difluoromethoxy)benzaldehyde
    3,4-dihydroxybenzaldehyde3,4-Bis(difluoromethoxy)benzaldehyde
    METHYL CHLORODIFLUOROACETATE+3,4-dihydroxybenzaldehyde3,4-Bis(difluoromethoxy)benzaldehyde+4-Difluoromethoxy-3-Hydroxybenzaldehyde

    Precursor

    METHYL CHLORODIFLUOROACETATE
    4-Difluoromethoxy-3-Hydroxybenzaldehyde
    Difluorochloromethane
    sodium,2-chloro-2,2-difluoroacetate

    Downstream Product

    5-[[3,4-bis(difluoromethoxy)phenyl]-chloromethyl]-2-bromopyridine
    [3,4-bis(difluoromethoxy)phenyl]methanol
    1-[3,4-bis(difluoromethoxy)phenyl]ethanone
    [3,4-bis(difluoromethoxy)phenyl]methanamine,hydrochloride

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