Home > Chiral Compounds> (2S,3S,5S)-2-(N,N-Dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane

(2S,3S,5S)-2-(N,N-Dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane

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Origin: China

Cas No: 156732-15-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 156732-15-9 Formula: C32H36N2O Molecular Weight: 464.64100

Description

(2S,3S,5S)-2-(N,N-Dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane is an intermediate in the synthesis of Lopinavir(L469480) and Ritonavir.

Basic Info

Chemical Name	(2S,3S,5S)-2-(N,N-Dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane
Synonyms	(2S,3S,5S)-5-Amino-2-(benzylamino)-1,6-diphenylhexan-3-ol;
CAS No.	156732-15-9
Molecular Formula	C32H36N2O
Molecular Weight	464.64100
PSA	49.49000
LogP	6.32140

Properties

Appearance & Physical State	Colourless thick oil
Density	1.125
Boiling Point	642.878ºC at 760 mmHg
Flash Point	342.601ºC
Refractive Index	1.624
Vapor Pressure	0mmHg at 25°C

Synthesis Route

(5S)-2-Amino-5-(N,N-dibenzylamino)-4-oxo-1,6-diphenylhex-2-ene→(2S,3S,5S)-2-(N,N-Dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane
(2S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-one→(2S,3S,5S)-2-(N,N-Dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane
(5S,1'S)-3-phenylmethyl-5-(1'-N,N-dibenzylamino-2'-phenylethyl)-2-isoxazoline→(2S,3S,5S)-2-(N,N-Dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane

Precursor

(5S)-2-Amino-5-(N,N-dibenzylamino)-4-oxo-1,6-diphenylhex-2-ene
(5S,1'S)-3-phenylmethyl-5-(1'-N,N-dibenzylamino-2'-phenylethyl)-2-isoxazoline
(2S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-one

Downstream Product

tert-butyl N-[(2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate
(2S)-N-[(2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
tert-Butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
(2S,3S,5S)-2-(2,6-Dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1,6-diphenylhexane

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