Home > Chiral Compounds> (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane

(2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane

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Origin: China

Cas No: 128018-44-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 128018-44-0 Formula: C18H19NO3 Molecular Weight: 297.34800

Basic Info

Chemical Name	(2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane
Synonyms	[(1S)-1-(2S)-oxiranyl-2-phenylethyl]-carbaMic acid phenylMethyl ester; (1S,2S)-Cbz epoxide; (1S,1'S)-1-(1'-N-benzyloxycarbonylamino-2'-phenyl)ethyloxirane; [S-(R,R)]-(1-oxiranyl-2-phenylethyl) carbamic acid phenylmethyl ester; (2S,3S)-1,2-Epoxy-3-(benzyloxycarbonyl-amino)-4-phenylbutane; (1S,2S)-1-(N-benzyloxycarbonyl)-amino-2-phenylethyl-oxirane; N-benzyloxycarbonyl-3(S)-amino-1,2(S)-epoxy-4-phenylbutane; erythro N-Cbz-phenylalanyl epoxide;
CAS No.	128018-44-0
Molecular Formula	C18H19NO3
Molecular Weight	297.34800
PSA	50.86000
LogP	3.31380

Properties

Density	1.205 g/cm3
Boiling Point	481.8ºC at 760 mmHg
Refractive Index	1.593

Synthesis Route

(3S)-1-chloro-2-hydroxy-3-N-benzyloxycarbonylamino-4-phenylbutane→(2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane+(2R,3S)-1,2-Epoxy-3-(benzyloxycarbonyl-amino)-4-phenylbutane
benzyl N-[(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate→(2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane
(2S,3S)-2-hydroxy-4-phenyl-3-(phenylmethoxycarbonylamino)butanoic acid→(2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane

Precursor

benzyl N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate
(S)-(S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoic (isobutyl carbonic) anhydride
N-benzyloxycarbonyl-3(S)-amino-2(R)-methanesulfonyloxy-4-phenyl-1-butanol
benzyl N-[(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate

Downstream Product

(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2S)-2-(methanesulfonamido)-3-naphthalen-2-ylsulfanylpropanoyl]amino]-4-phenylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
(3S,4aS,8aS)-2-[(3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide

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